TY - JOUR
T1 - Pro-healing effects of morin, a natural antioxidant, on normal and dexamethasone-impaired wounds
AU - Shenoy, Rekha Raghuveer
AU - Sudheendra, Arun Theerthahalli
AU - Nayak, Pawan Ganesh
AU - Paul, Piya
AU - Kutty, Nampurath Gopalan
AU - Rao, Chamallamudi Mallikarjuna
PY - 2011/12
Y1 - 2011/12
N2 - Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.
AB - Background: The aim of the study was to investigate the effects of morin on skin breaking strength, hydroxyproline, lysyl oxidase, DNA and RNA content of experimentally infl icted wounds in rats. Methods: This study was performed on albino rats of either sex at the Central Animal Research Facility (CARF), Manipal University. Results: Morin showed signifi cant wound contraction on day 7 as compared to control with mean closure of 47.44 ± 6.07 % in excision wound model. Granulation tissue breaking strength was signifi cantly increased (p < 0.05) in the morin treated group with 180.2 ± 7.94 g when compared to control at 151.2 ± 6.99 g. There was a signifi cant increase in hydroxyproline content with the morin treated group when compared to control with 3.41 ± 0.33 μ g/mg of granulation tissue. Similarly, the wound parameters were improved with the morin treated group in dexamethasone delayed healing. Conclusions: Our results suggest that morin treatment accelerates the healing process delayed by concurrent use of steroids.
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U2 - 10.1515/JBCPP.2011.022
DO - 10.1515/JBCPP.2011.022
M3 - Article
C2 - 22865434
AN - SCOPUS:84856865746
SN - 0334-1534
VL - 22
SP - 131
EP - 135
JO - Journal of Basic and Clinical Physiology and Pharmacology
JF - Journal of Basic and Clinical Physiology and Pharmacology
IS - 4
ER -