TY - JOUR
T1 - Prognostic role of 14q32.31 miRNA cluster in various carcinomas
T2 - a systematic review and meta-analysis
AU - Jishnu, Padacherri Vethil
AU - Jayaram, Pradyumna
AU - Shukla, Vaibhav
AU - Varghese, Vinay Koshy
AU - Pandey, Deeksha
AU - Sharan, Krishna
AU - Chakrabarty, Sanjiban
AU - Satyamoorthy, Kapaettu
AU - Kabekkodu, Shama Prasada
PY - 2020/2/1
Y1 - 2020/2/1
N2 - Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.
AB - Deregulated miR-379/miR-656 cluster expression is considered as important for carcinogenesis and can be used as a potential prognostic marker. Hence, the meta-analysis was conducted to test the utility of miR-379/miR-656 cluster as a prognostic marker in various cancers. A literature search was performed using Web of Science, PubMed and Cochrane Library to obtain relevant studies and were subjected to various subgroup and bioinformatics analyses. Selected twenty-three studies contained 13 cancer types comprising of 3294 patients from 7 nations. Univariate and multivariate data showed an association of high expression of miRNAs with the poor prognosis of cancer patients (p < 0.001). The subgroup analysis showed that lung cancer, breast cancer and papillary renal cell carcinoma (p < 0.001) have a negative association with the survival of patients. Our study is the first meta-analysis showing the association of miR-379/miR-656 cluster expression and overall survival, suggesting its potential as a prognostic indicator in multiple cancers.
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U2 - 10.1007/s10585-019-10013-2
DO - 10.1007/s10585-019-10013-2
M3 - Review article
AN - SCOPUS:85076097648
SN - 0262-0898
JO - Clinical and Experimental Metastasis
JF - Clinical and Experimental Metastasis
ER -
