TY - JOUR
T1 - Protein kinase C-mediated sodium glucose transporter 1 activation in precondition-induced cardioprotection
AU - Kanwal, Abhinav
AU - Kasetti, Sujatha
AU - Putcha, Uday Kumar
AU - Asthana, Shailendra
AU - Banerjee, Sanjay K.
PY - 2016/9/14
Y1 - 2016/9/14
N2 - The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relationship between PKC and sodium glucose transporter 1 (SGLT1) in preconditioning-induced cardioprotection, which is ill reported till now. By applying a multifaceted approach, we demonstrated that PKC activates SGLT1, which curbed oxidative stress and apoptosis against I/R injury. PKC activation enhances cardiac glucose uptake through SGLT1 and seems essential in preventing I/R-induced cardiac injury, indicating a possible cross-talk between PKC and SGLT1.
AB - The concept of cardioprotection through preconditioning against ischemia-reperfusion (I/R) injury is well known and established. However, among different proposed mechanisms regarding the concept of ischemic preconditioning, protein kinase C (PKC)-mediated cardioprotection through ischemic preconditioning plays a key role in myocardial I/R injury. Thus, this study was designed to find the relationship between PKC and sodium glucose transporter 1 (SGLT1) in preconditioning-induced cardioprotection, which is ill reported till now. By applying a multifaceted approach, we demonstrated that PKC activates SGLT1, which curbed oxidative stress and apoptosis against I/R injury. PKC activation enhances cardiac glucose uptake through SGLT1 and seems essential in preventing I/R-induced cardiac injury, indicating a possible cross-talk between PKC and SGLT1.
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U2 - 10.2147/DDDT.S105482
DO - 10.2147/DDDT.S105482
M3 - Article
C2 - 27695290
AN - SCOPUS:84989172199
SN - 1177-8881
VL - 10
SP - 2929
EP - 2938
JO - Drug Design, Development and Therapy
JF - Drug Design, Development and Therapy
ER -