Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study

Suraj Menon; Sujatha; K. Kalyan Kumar; Jacob Kurien; B. R. Krishnanand; K. K. Mahato; Sajan D. George; V. B. Kartha; C. Santhosh

doi:10.1117/12.699935

Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study

Suraj Menon, Sujatha, K. Kalyan Kumar, Jacob Kurien, B. R. Krishnanand, K. K. Mahato, Sajan D. George, V. B. Kartha, C. Santhosh

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

6 Citations (SciVal)

Abstract

Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.

Original language	English
Title of host publication	Advanced Biomedical and Clinical Diagnostic Systems V
Volume	6430
DOIs	https://doi.org/10.1117/12.699935
Publication status	Published - 2007
Event	Advanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States Duration: 21-01-2007 → 27-01-2007

Conference

Conference	Advanced Biomedical and Clinical Diagnostic Systems V
Country/Territory	United States
City	San Jose, CA
Period	21-01-07 → 27-01-07

All Science Journal Classification (ASJC) codes

Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.699935

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@inproceedings{17e975c11bf743e392f744c5eca1ddac,

title = "Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study",

abstract = "Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.",

author = "Suraj Menon and Sujatha and Kumar, {K. Kalyan} and Jacob Kurien and Krishnanand, {B. R.} and Mahato, {K. K.} and George, {Sajan D.} and Kartha, {V. B.} and C. Santhosh",

year = "2007",

doi = "10.1117/12.699935",

language = "English",

isbn = "0819465437",

volume = "6430",

booktitle = "Advanced Biomedical and Clinical Diagnostic Systems V",

note = "Advanced Biomedical and Clinical Diagnostic Systems V ; Conference date: 21-01-2007 Through 27-01-2007",

}

Menon, S, Sujatha, Kumar, KK, Kurien, J, Krishnanand, BR, Mahato, KK , George, SD, Kartha, VB & Santhosh, C 2007, Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study. in Advanced Biomedical and Clinical Diagnostic Systems V. vol. 6430, 64300W, Advanced Biomedical and Clinical Diagnostic Systems V, San Jose, CA, United States, 21-01-07. https://doi.org/10.1117/12.699935

TY - GEN

T1 - Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study

AU - Menon, Suraj

AU - Sujatha,

AU - Kumar, K. Kalyan

AU - Kurien, Jacob

AU - Krishnanand, B. R.

AU - Mahato, K. K.

AU - George, Sajan D.

AU - Kartha, V. B.

AU - Santhosh, C.

PY - 2007

Y1 - 2007

N2 - Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.

AB - Proteomics based techniques are rapidly emerging as alternative techniques to conventional histo-pathological methods for detection and diagnosis of cancers. Tumor markers are of considerable importance in the study of various cancers. A study of various changes in the protein profile associated with breast cancer will facilitate a better understanding of the various dynamic changes associated with the disease. In our study we have used High Performance Liquid Chromatography coupled with highly sensitive Laser Induced Fluorescence for recording the protein profiles of breast tissue homogenates. The protein profiles were recorded from pathologically certified normal as well as malignant breast tissue samples. The recorded protein profiles were studied by using Principal Component Analysis. Good discrimination of normal, benign and malignant samples was achieved in this pilot study.

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U2 - 10.1117/12.699935

DO - 10.1117/12.699935

M3 - Conference contribution

AN - SCOPUS:34247391922

SN - 0819465437

SN - 9780819465436

VL - 6430

BT - Advanced Biomedical and Clinical Diagnostic Systems V

T2 - Advanced Biomedical and Clinical Diagnostic Systems V

Y2 - 21 January 2007 through 27 January 2007

ER -

Protein profile study of breast cancer tissues using HPLC-LIF- A pilot study

Abstract

Conference

All Science Journal Classification (ASJC) codes

UN SDGs

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