Protein profile study of clinical samples using laser induced fluorescence as the detection method: Case of malignant and normal cervical tissues

Gopal Karemore; Sujatha Sujatha; Lavanya Rai; V. B. Kartha; C. Santhosh

doi:10.1117/12.809972

Protein profile study of clinical samples using laser induced fluorescence as the detection method: Case of malignant and normal cervical tissues

Gopal Karemore, Sujatha, Lavanya Rai, V. B. Kartha, C. Santhosh^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.

Original language	English
Article number	71691I
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7169
DOIs	https://doi.org/10.1117/12.809972
Publication status	Published - 08-06-2009
Event	Advanced Biomedical and Clinical Diagnostic Systems VII - San Jose, CA, United States Duration: 25-01-2009 → 26-01-2009

All Science Journal Classification (ASJC) codes

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1117/12.809972

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abstract = "Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.",

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AU - Santhosh, C.

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AB - Protein profiles of tissue homogenates were recorded using HPLC separation and LIF detection method. The samples were collected from volunteers with clinically normal or cervical cancer conditions. It is shown that the protein profile can be classified as belonging to malignant or normal state by using hard and Fuzzy clustering methods. The study was performed to test the utility of the HPLC-LIF protein profiling method for classification of tissue samples as well as to establish a complementary method for histopathology for clinical diagnosis of the tissue as normal or malignant.

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Protein profile study of clinical samples using laser induced fluorescence as the detection method: Case of malignant and normal cervical tissues

Abstract

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