TY - JOUR
T1 - Pulmonary toxicity of bleomycin - A case series from a tertiary care center in southern India
AU - Patil, Navin
AU - Paulose, Rinz Mathew
AU - Udupa, Karthik Subramanya
AU - Ramakrishna, Narayanan
AU - Ahmed, Talha
N1 - Publisher Copyright:
© 2016, Journal of Clinical and Diagnostic Research. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Hodgkin’s lymphoma is one of the curable cancers and the standard treatment regimen involves combination chemotherapy involving bleomycin. One of the fatal side effect of bleomycin is pulmonary toxicity. Here we present three cases of Hodgkin’s lymphoma treated with ABVD chemotherapy who had pulmonary toxicity. All three developed bleomycin induced pulmonary toxicity in the form of pulmonary fibrosis during treatment of the disease. Mode of treatment, severity of the condition and the treatment outcome varied among the three.Two recovered following treatment and one patient died due to irreversible pulmonary damage. Causality assessment using Naranjo’s scale gave a score of 7 for case one and three and a score of 6 for case two, both indicating the adverse drug reaction to be a probable bleomycin induced Lung fibrosis.
AB - Hodgkin’s lymphoma is one of the curable cancers and the standard treatment regimen involves combination chemotherapy involving bleomycin. One of the fatal side effect of bleomycin is pulmonary toxicity. Here we present three cases of Hodgkin’s lymphoma treated with ABVD chemotherapy who had pulmonary toxicity. All three developed bleomycin induced pulmonary toxicity in the form of pulmonary fibrosis during treatment of the disease. Mode of treatment, severity of the condition and the treatment outcome varied among the three.Two recovered following treatment and one patient died due to irreversible pulmonary damage. Causality assessment using Naranjo’s scale gave a score of 7 for case one and three and a score of 6 for case two, both indicating the adverse drug reaction to be a probable bleomycin induced Lung fibrosis.
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U2 - 10.7860/JCDR/2016/18773.7626
DO - 10.7860/JCDR/2016/18773.7626
M3 - Article
AN - SCOPUS:84963516773
SN - 2249-782X
VL - 10
SP - FR01-FR03
JO - Journal of Clinical and Diagnostic Research
JF - Journal of Clinical and Diagnostic Research
IS - 4
ER -