Quantitation of proteinuria using protein-creatinine ratio in random urine samples.

R. S. Iyer, S. N. Shailaja, N. Bhaskaranand, M. Baliga, A. Venkatesh

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14 Citations (Scopus)


Estimation of proteinuria in children is cumbersome when a 24 h urine collection is needed. In the presence of a stable glomerular filtration rate, the ratio of urinary protein and creatinine should reflect the protein excretion. One hundred samples of urine (24 h and random samples) were collected from 50 children with nephrotic syndrome, 25 with nephrotic syndrome in remission and 25 normal children. The 24 h urine total protein and random urine protein-creatinine ratio were assessed on these samples. Linear regression analysis of the results showed excellent correlation between the values (r = 0.81, p less than 0.001). A random urine protein-creatinine ratio of greater than 3.5 correlated with massive proteinuria, while a ratio less than 0.2 was suggestive of physiological values. The sensitivity, specificity, positive and negative predictive values of the protein-creatinine ratio in massive proteinuria were very high. We conclude that the random urine protein-creatinine ratio can be used reliably to assess the degree of proteinuria in children.

Original languageEnglish
Pages (from-to)463-467
Number of pages5
JournalIndian Pediatrics
Issue number5
Publication statusPublished - 01-05-1991

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health


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