TY - JOUR
T1 - QUANTITATIVE DETERMINATION AND VALIDATION OF ETORICOXIB AND PARACETAMOL COMBINED TABLET DOSAGE FORM BY REVERSE PHASE-HPLC
AU - Goudar, Nandini
AU - Tejas, Bharathi
AU - Sathyanarayana, Muddukrishna Badamane
AU - Pai, Aravind
AU - Pai, Vasudev
N1 - Funding Information:
The authors are thankful to the Department of Pharmaceutical Chemistry, Vivekananda College of Pharmacy, Bengaluru, Department of Quality Assurance, Analytica Chemie Inc. Peenya, Bengaluru, and Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, and Manipal Academy of Higher Education for providing laboratory facilities and other infrastructure to carry out the work.
Publisher Copyright:
© 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - An RP-HPLC technique was used to produce a cost-effective simultaneous quantification of Etoricoxib and Paracetamol in combined pharmaceutical tablet dosage forms. The approach was validated for Etoricoxib and Paracetamol using ICH recommendations over a range of 20-120ppm and 20-200ppm, respectively. At a temperature of 250 C±0.50 C, an analytical column PURITAS™ EXIMIUS C18, 250mmx4.6mm, 5 microns was utilized. At a flow rate of 1.0 ml/min, the mobile phase was acetonitrile and 0.1 percent acetic acid in water in a 70:30V/V ratio. The elution was examined using a PDA detector with a detection wavelength of 235nm. The retention times for Etoricoxib and paracetamol are 4.2 and 2.1 minutes, respectively. The percentage recoveries for Etoricoxib and paracetamol were 98.28% and 102.1%, respectively. The RSD values are not greater than 2%.
AB - An RP-HPLC technique was used to produce a cost-effective simultaneous quantification of Etoricoxib and Paracetamol in combined pharmaceutical tablet dosage forms. The approach was validated for Etoricoxib and Paracetamol using ICH recommendations over a range of 20-120ppm and 20-200ppm, respectively. At a temperature of 250 C±0.50 C, an analytical column PURITAS™ EXIMIUS C18, 250mmx4.6mm, 5 microns was utilized. At a flow rate of 1.0 ml/min, the mobile phase was acetonitrile and 0.1 percent acetic acid in water in a 70:30V/V ratio. The elution was examined using a PDA detector with a detection wavelength of 235nm. The retention times for Etoricoxib and paracetamol are 4.2 and 2.1 minutes, respectively. The percentage recoveries for Etoricoxib and paracetamol were 98.28% and 102.1%, respectively. The RSD values are not greater than 2%.
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U2 - 10.31788/RJC.2022.1537027
DO - 10.31788/RJC.2022.1537027
M3 - Article
AN - SCOPUS:85136183039
SN - 0974-1496
VL - 15
SP - 1702
EP - 1708
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 3
ER -