TY - JOUR
T1 - Quantitative estimation and evaluation of anti-inflammatory activity of macromolecules of Boswellia serrata
AU - Sampath, V.
AU - Mukhopadhyay, Nabarun
AU - Pai, Sameer
AU - Dilip, N.
AU - Sai Sandeep, M.
AU - Babu, U. V.
AU - Lobo, Richard
AU - Pai, Vasudev
N1 - Funding Information:
The authors acknowledge Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal and The Himalaya Drug Company, Bangalore for their support by providing important information and infrastructure facilities.
Publisher Copyright:
© 2021, National Institute of Science Communication and Information Resources. All rights reserved.
PY - 2021/10
Y1 - 2021/10
N2 - The present study was aimed to isolate and perform qualitative analysis of macromolecules present in Boswellia serrata followed by evaluation of their anti-inflammatory activity by in-vitro IL-6 ELISA study. The oleo gum resin of B. serrata was pretreated with hexane, methanol and the obtained residue was extracted with water and the final dried powder was taken for macromolecule analysis. The macromolecules which comprise of polysaccharides, mucilages and proteins were quantitatively estimated and evaluated for their anti-inflammatory activity by in-vitro IL-6 ELISA study. From the current study, it was found that the macromolecules present in B. serrata majorly comprise of polysaccharides and mucilages with moderate quantity of proteins. The quantitative analysis of polysaccharides, mucilages and proteins were found 35.91%, 34% and 14.29%. From the in-vitro IL-6 ELISA study, it was found that the macromolecules showed 82.63% inhibition of IL-6. The identified macromolecules from B. serrata showed significant anti-inflammatory activity by inhibition of IL-6 and further need to confirm by in vivo study to qualify B. serrata macromolecules as a promising anti-inflammatory agent.
AB - The present study was aimed to isolate and perform qualitative analysis of macromolecules present in Boswellia serrata followed by evaluation of their anti-inflammatory activity by in-vitro IL-6 ELISA study. The oleo gum resin of B. serrata was pretreated with hexane, methanol and the obtained residue was extracted with water and the final dried powder was taken for macromolecule analysis. The macromolecules which comprise of polysaccharides, mucilages and proteins were quantitatively estimated and evaluated for their anti-inflammatory activity by in-vitro IL-6 ELISA study. From the current study, it was found that the macromolecules present in B. serrata majorly comprise of polysaccharides and mucilages with moderate quantity of proteins. The quantitative analysis of polysaccharides, mucilages and proteins were found 35.91%, 34% and 14.29%. From the in-vitro IL-6 ELISA study, it was found that the macromolecules showed 82.63% inhibition of IL-6. The identified macromolecules from B. serrata showed significant anti-inflammatory activity by inhibition of IL-6 and further need to confirm by in vivo study to qualify B. serrata macromolecules as a promising anti-inflammatory agent.
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M3 - Article
AN - SCOPUS:85119041579
SN - 0972-5938
VL - 20
SP - 940
EP - 943
JO - Indian Journal of Traditional Knowledge
JF - Indian Journal of Traditional Knowledge
IS - 4
ER -