Radioiodine therapy of Graves' disease and the uptake paradox

Sumeet Suresh Malapure, Anirban Mukherjee, Chandrasekar Bal

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Purpose of the Study: Radioiodine (131I) therapy is approved and well-Accepted modality for the treatment of hyperthyroidism. The dosage of131I for successful treatment is based on many factors; however, an objective tool to determine the dose was missing. In a retrospective study, we found that high131I uptake values required more dose to achieve desirable results contrary to the belief. Materials and Methods: Clinically and scintigraphically proven Graves' disease patients with high131I uptake (>50%) were accrued for this study and block randomized into low-dose (Group I) and high-dose (Group II) groups. Low activity (5 mCi) was administered in Group I and higher activity (10 mCi) in Group II. The patients were followed up after 3 months with thyroid function tests to determine the outcome. Results: A total of 344 patients were analyzed at the end of 3 months, with 174 in low-dose group and 170 in high-dose group. Euthyroidism/hypothyroidism was achieved in significantly higher number of patients as compared to the low-dose group. Conclusion: The higher dose of131I is required to achieve euthyroidism/hypothyroidism in patients with high131I uptake.

Original languageEnglish
Pages (from-to)17-20
Number of pages4
JournalIndian Journal of Nuclear Medicine
Issue number1
Publication statusPublished - 01-01-2020
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging


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