TY - JOUR
T1 - Radioprotective effect of ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure
AU - Joseph, Lebana J.
AU - Bhartiya, Uma S.
AU - Raut, Yogita S.
AU - Hawaldar, Rohini W.
AU - Nayak, Yogendra
AU - Pawar, Yogita P.
AU - Jambhekar, Nirmala A.
AU - Rajan, M. G R
PY - 2011/12/1
Y1 - 2011/12/1
N2 - The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ( 131I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) 131I exposure. Six months duration batch received 131I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before 131I exposure separately. Increased Technetium-99m-pertechnetate ( 99mTcO 4 -) uptake at 30 minutes post injection in salivary glands of only 131I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only 131I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to 131I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose 131I exposure.
AB - The current study investigated the radioprotective effect of Ocimum sanctum on the salivary gland of rats administered radioiodine ( 131I) and compared its efficacy with a known radioprotectant, amifostine. The experimental rats were divided in four groups and sacrificed in three different batches at 1, 3, and 6 months of time interval after 18.5 MBq/100g (i.p.) 131I exposure. Six months duration batch received 131I exposure twice with the gap of 3 months. Two groups of experimental rats were presupplemented with O. sanctum (40 mg/kg for 5 days, orally) and amifostine (200 mg/kg, s.c) before 131I exposure separately. Increased Technetium-99m-pertechnetate ( 99mTcO 4 -) uptake at 30 minutes post injection in salivary glands of only 131I exposed rats may imply delay in clearance at 6 months of exposure in comparison to their counterparts sacrificed at 1 month. Parotid gland histology showed atrophy with lipomatosis in only 131I exposed rats at 3 and 6 months of duration. O. sanctum and amifostine presupplemented and subsequently exposed to 131I rats at 3 and 6 months duration exhibited comparable histopathology with controls. Our study indicates possible radioprotective effect of O. sanctum and amifostine against high-dose 131I exposure.
UR - https://www.scopus.com/pages/publications/83455262994
UR - https://www.scopus.com/pages/publications/83455262994#tab=citedBy
U2 - 10.1089/cbr.2011.1014
DO - 10.1089/cbr.2011.1014
M3 - Article
C2 - 22087607
AN - SCOPUS:83455262994
SN - 1084-9785
VL - 26
SP - 737
EP - 743
JO - Cancer Biotherapy and Radiopharmaceuticals
JF - Cancer Biotherapy and Radiopharmaceuticals
IS - 6
ER -
