Radioprotective effect of Phyllanthus niruri on mouse chromosomes

P. Uma Devi; Ravindra Kamath; B. S S Rao

Radioprotective effect of Phyllanthus niruri on mouse chromosomes

P. Uma Devi^*
, Ravindra Kamath
, B. S S Rao

^*Corresponding author for this work

Department of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50% methanolic extract of Phyllanthus niruri (whole aerial part). The extract significantly reduced the radiation-induced MN induction in both PCE and NCE and increased the ratio of PCE to NCE. The effect increased linearly with extract dose from 25 to 125 mg/kg.

Original language	English
Pages (from-to)	1245-1247
Number of pages	3
Journal	Current Science
Volume	78
Issue number	10
Publication status	Published - 25-05-2000

All Science Journal Classification (ASJC) codes

General

Cite this

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title = "Radioprotective effect of Phyllanthus niruri on mouse chromosomes",

abstract = "Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50\% methanolic extract of Phyllanthus niruri (whole aerial part). The extract significantly reduced the radiation-induced MN induction in both PCE and NCE and increased the ratio of PCE to NCE. The effect increased linearly with extract dose from 25 to 125 mg/kg.",

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T1 - Radioprotective effect of Phyllanthus niruri on mouse chromosomes

AU - Uma Devi, P.

AU - Kamath, Ravindra

AU - Rao, B. S S

PY - 2000/5/25

Y1 - 2000/5/25

N2 - Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50% methanolic extract of Phyllanthus niruri (whole aerial part). The extract significantly reduced the radiation-induced MN induction in both PCE and NCE and increased the ratio of PCE to NCE. The effect increased linearly with extract dose from 25 to 125 mg/kg.

AB - Micronuclei (MN) induction in the mouse bone marrow polychromatic erythrocytes (PCE) and normochromatic erythrocytes (NCE) was studied 24 h after whole body exposure to 4 Gy of gamma radiation with or without a single intraperitoneal injection of 25 mg/kg to 150 mg/kg of 50% methanolic extract of Phyllanthus niruri (whole aerial part). The extract significantly reduced the radiation-induced MN induction in both PCE and NCE and increased the ratio of PCE to NCE. The effect increased linearly with extract dose from 25 to 125 mg/kg.

UR - https://www.scopus.com/pages/publications/0001213419

UR - https://www.scopus.com/pages/publications/0001213419#tab=citedBy

M3 - Article

AN - SCOPUS:0001213419

SN - 0011-3891

VL - 78

SP - 1245

EP - 1247

JO - Current Science

JF - Current Science

IS - 10

ER -

Radioprotective effect of Phyllanthus niruri on mouse chromosomes

Abstract

All Science Journal Classification (ASJC) codes

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