Raman spectroscopy for viral diagnostics

Jijo Lukose; Ajaya Kumar Barik; N Mithun N; Pavithran M Sanoop Pavithran M; Sajan D. George; V. M. Murukeshan; Santhosh Chidangil

doi:10.1007/s12551-023-01059-4

Raman spectroscopy for viral diagnostics

Jijo Lukose, Ajaya Kumar Barik, N Mithun N, Pavithran M Sanoop Pavithran M, Sajan D. George, V. M. Murukeshan, Santhosh Chidangil^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. Graphical abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	199-221
Number of pages	23
Journal	Biophysical Reviews
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/s12551-023-01059-4
Publication status	Published - 04-2023

All Science Journal Classification (ASJC) codes

Biophysics
Structural Biology
Molecular Biology

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title = "Raman spectroscopy for viral diagnostics",

abstract = "Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. Graphical abstract: [Figure not available: see fulltext.].",

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AU - Lukose, Jijo

AU - Barik, Ajaya Kumar

AU - Mithun N, N

AU - Sanoop Pavithran M, Pavithran M

AU - George, Sajan D.

AU - Murukeshan, V. M.

AU - Chidangil, Santhosh

PY - 2023/4

Y1 - 2023/4

N2 - Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. Graphical abstract: [Figure not available: see fulltext.].

AB - Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. Graphical abstract: [Figure not available: see fulltext.].

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Raman spectroscopy for viral diagnostics

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