TY - JOUR
T1 - Recent advancements in spectrophotometric pka determinations
T2 - A review
AU - Berkhout, Job Herman
AU - Aswatha Ram, H. N.
PY - 2019/10/1
Y1 - 2019/10/1
N2 - The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.
AB - The pKa value is a key feature in Absorption, Distribution, Metabolism and Excretion (ADME) of drugs, thus knowing this value is critical in drug development. In this review, pKa values determined in the past decade, using UV-Vis spectrometry, are discussed. To determine the pKa, four methods were applied; Henderson-Hasselbach, Albert-Serjeant, Bates-Schwarzenbach and Spectrometric titrations. This review will show the value of this aged but well-established technique in the past decade, due to its simplicity, accuracy, cost efficiency and reproducibility.
UR - http://www.scopus.com/inward/record.url?scp=85075220341&partnerID=8YFLogxK
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U2 - 10.5530/ijper.53.4s.141
DO - 10.5530/ijper.53.4s.141
M3 - Article
AN - SCOPUS:85075220341
SN - 0019-5464
VL - 53
SP - S475-S480
JO - Indian Journal of Pharmaceutical Education and Research
JF - Indian Journal of Pharmaceutical Education and Research
IS - 4
ER -