Recent Advances in the Surfactant and Controlled Release Polymer-based Solid Dispersion

Aman Gupta, Gourav Paudwal, Rigzin Dolkar, Shaila Lewis, Prem N. Gupta

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The oral route is the most preferred delivery route for drug administration due to its advantages, such as lower cost, improved patient compliance, no need for trained personnel, and less severity of drug reactions in general. The major problem with new molecules in the drug discovery pipeline is poor solubility and dissolution rate that ultimately results in low oral bioavailability. Numerous techniques are available for solubility and bioavailability (BA) enhancement, but out of all, solid dispersion (SD) is proven to be the most feasible due to fewer issues in manufacturing, processing, storage, and transportation. In the past few years, SD has been ex-tensively applied to reinforce the common issues of insoluble drugs. Currently, many hydrophobic and hydro-philic polymers are used to prepare either immediate release or controlled release SDs. Therefore, the biological behavior of the SDs is contingent upon the use of appropriate polymeric carriers and methods of preparation. The exploration of novel carriers and methodologies in SD technology leads to improved BA and therapeutic effectiveness. Moreover, the clinical applicability of SD-based formulations has been increased with the discovery of novel polymeric carriers. In this review, emphasis is laid down on the present status of recent genera-tions of SDs (i.e., surfactant and controlled release polymer-based SD) and their application in modifying the physical properties of the drug and modulation of pharmacological response in different ailments.

Original languageEnglish
Pages (from-to)1643-1659
Number of pages17
JournalCurrent Pharmaceutical Design
Volume28
Issue number20
DOIs
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

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