TY - JOUR
T1 - Regioselective reaction
T2 - synthesis and biological properties of some novel mannich bases incorporating arylnitro thiophene moiety
AU - Babu, M.
AU - Sujatha, K.
AU - Shenoy, S. Shalini
AU - Kalluraya, Balakrishna
PY - 2009/1/1
Y1 - 2009/1/1
N2 - The Mannich reaction of 3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino- 5-mercapto-1,2,4-triazoles (3) with formaldehyde and appropriate amine resulted in the regioselective formation of 1-aminomethyl-3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino-1,2,4-triazole-5-thiones (4). The structures of the new compounds were established on the basis of analytical and spectral data. The new compounds were tested for their antibacterial and antifungal activities. Most of the tested compounds showed significant antifungal activity, much higher than the standard.
AB - The Mannich reaction of 3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino- 5-mercapto-1,2,4-triazoles (3) with formaldehyde and appropriate amine resulted in the regioselective formation of 1-aminomethyl-3-(substituted)-4-[5-(p-nitrophenyl)-2- thienylidene] amino-1,2,4-triazole-5-thiones (4). The structures of the new compounds were established on the basis of analytical and spectral data. The new compounds were tested for their antibacterial and antifungal activities. Most of the tested compounds showed significant antifungal activity, much higher than the standard.
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M3 - Article
AN - SCOPUS:67650657783
SN - 0971-1627
VL - 18
SP - 259
EP - 262
JO - Indian Journal of Heterocyclic Chemistry
JF - Indian Journal of Heterocyclic Chemistry
IS - 3
ER -