TY - JOUR
T1 - Regiospecific reaction
T2 - Synthesis and biological assay of some sydnone and triazole-containing Mannich derivatives
AU - Kalluraya, Balakrishna
AU - Rai, Ganesha
AU - Rai, Satheesha
AU - Shenoy, Shalini
PY - 2004/10/1
Y1 - 2004/10/1
N2 - Condensation of 3-substituted-4-amino-1,2,4-triazole-5-thiones 3 with 3-aryl-sydnone-4-carboxaldehyde 5 afforded a series of Schiff's bases 6. These Schiff's bases underwent Mannich reaction regiospecifically with morpholine and formaldehyde to give Mannich bases 7. The new compounds were characterized by spectral and analytical data. Biological screening results showed promising antibacterial and antifungal activities for these compounds.
AB - Condensation of 3-substituted-4-amino-1,2,4-triazole-5-thiones 3 with 3-aryl-sydnone-4-carboxaldehyde 5 afforded a series of Schiff's bases 6. These Schiff's bases underwent Mannich reaction regiospecifically with morpholine and formaldehyde to give Mannich bases 7. The new compounds were characterized by spectral and analytical data. Biological screening results showed promising antibacterial and antifungal activities for these compounds.
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M3 - Article
AN - SCOPUS:18244369722
SN - 0971-1627
VL - 14
SP - 127
EP - 130
JO - Indian Journal of Heterocyclic Chemistry
JF - Indian Journal of Heterocyclic Chemistry
IS - 2
ER -