Rekürren ailesel hidatidiform mol - nadir bir klinik problem

Translated title of the contribution: Recurrent familial hydatidiform mole - a rare clinical problem

Lavanya Rai, Hebbar Shripad, Shyamala Guruvayare, Adiga Prashant, Anjali Sunil

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Familial recurrent hydatidiform mole is a rare event; here we report an unusual case of a gravida 5 aged 29 years, with five recurrent hydatidiform moles and no normal pregnancy. After the fourth molar pregnancy, she developed persistent trophoblastic disease that required 7 cycles of single agent chemotherapy. Two years after the treatment, she presented with her fifth molar pregnancy. Her elder sister had seven hydatidiform moles from two different unrelated male partners. As this is familial, and recurrent, with no viable conceptions in both the sisters, it is likely to be biparental in origin. Unlike androgenetic moles, biparental moles arise due to a global inherited failure of maternal imprinting. It is an autosomal recessive defect in the female germ line. Genetic analysis is essential, although it is not available in all centers. Donor Oocyte IVF is the only option for women with biparental moles to have normal offspring.

Translated title of the contributionRecurrent familial hydatidiform mole - a rare clinical problem
Original languageTurkish
Pages (from-to)284-286
Number of pages3
JournalJournal of the Turkish German Gynecology Association
Issue number4
Publication statusPublished - 01-12-2012

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology


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