TY - JOUR
T1 - Remedial effects of caffeine against depressive-like behaviour in mice by modulation of neuroinflammation and BDNF
AU - Basu Mallik, Sanchari
AU - Mudgal, Jayesh
AU - Hall, Susan
AU - Kinra, Manas
AU - Grant, Gary D.
AU - Nampoothiri, Madhavan
AU - Anoopkumar-Dukie, Shailendra
AU - Arora, Devinder
N1 - Funding Information:
This study was financially supported by QUM Network Research Grant Scheme, Griffith University to DA. ‘2018 Endeavour Australia India Education Council Research Fellowship’ to Dr Sanchari Basu Mallik for her postdoctoral research at Griffith University is truly acknowledged. The authors also thank Dr KSR Pai, Head of Pharmacology Department, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education (MAHE), Manipal for providing facilities to carry out a part of this project.
Publisher Copyright:
© 2021 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2022
Y1 - 2022
N2 - Objective: Caffeine (CAF) is one of the most commonly consumed nutritional stimulant in beverages. Interestingly, CAF produces varied effects in a dose-dependent manner, and that makes it one of the most controversial nutritional ingredients. Various studies have linked CAF consumption and reduced risk of depressive disorders. The aim of this study was to investigate the effect of CAF on lipopolysaccharide (LPS)-induced neuroinflammation and depressive-like behaviour. Methods: C57BL/6J male mice were divided into four groups consisting of saline (SAL), LPS, CAF and Imipramine (IMI). Animals were pretreated orally with CAF (10 mg/kg) and IMI (10 mg/kg) for 14 days once daily and all groups except SAL were challenged with LPS (0.83 mg/kg) intraperitoneally on day 14. Results: LPS produced a biphasic behavioural response with a significantly high immobility time and weight loss after 24 h. The brain cytokines (TNF-α, IL-6, IL-1β, and IFN-γ) levels were remarkably high, along with increased lipid peroxidation and reduced Brain Derived Neurotrophic Factor (BDNF). These biochemical and behavioural changes were significantly alleviated by CAF and IMI chronic treatment. Conclusion: The results of this study implicate that mild-moderate consumption of CAF could impart anti-inflammatory properties under neuroinflammatory conditions by modulating the cytokine and neurotrophic mechanisms.
AB - Objective: Caffeine (CAF) is one of the most commonly consumed nutritional stimulant in beverages. Interestingly, CAF produces varied effects in a dose-dependent manner, and that makes it one of the most controversial nutritional ingredients. Various studies have linked CAF consumption and reduced risk of depressive disorders. The aim of this study was to investigate the effect of CAF on lipopolysaccharide (LPS)-induced neuroinflammation and depressive-like behaviour. Methods: C57BL/6J male mice were divided into four groups consisting of saline (SAL), LPS, CAF and Imipramine (IMI). Animals were pretreated orally with CAF (10 mg/kg) and IMI (10 mg/kg) for 14 days once daily and all groups except SAL were challenged with LPS (0.83 mg/kg) intraperitoneally on day 14. Results: LPS produced a biphasic behavioural response with a significantly high immobility time and weight loss after 24 h. The brain cytokines (TNF-α, IL-6, IL-1β, and IFN-γ) levels were remarkably high, along with increased lipid peroxidation and reduced Brain Derived Neurotrophic Factor (BDNF). These biochemical and behavioural changes were significantly alleviated by CAF and IMI chronic treatment. Conclusion: The results of this study implicate that mild-moderate consumption of CAF could impart anti-inflammatory properties under neuroinflammatory conditions by modulating the cytokine and neurotrophic mechanisms.
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U2 - 10.1080/1028415X.2021.1906393
DO - 10.1080/1028415X.2021.1906393
M3 - Article
AN - SCOPUS:85103667504
SN - 1028-415X
VL - 25
SP - 1836
EP - 1844
JO - Nutritional Neuroscience
JF - Nutritional Neuroscience
IS - 9
ER -