Resource-appropriate selection of osteosarcoma treatment protocols in low- and middle-income countries

Sharada Mailankody, Venkatesan Sampath Kumar, Shah Alam Khan, Shripad D. Banavali, Jyoti Bajpai

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)

Abstract

Osteosarcoma is a rare malignancy; however, it is still the most common primary bone tumor in adolescents and young adults. Chemotherapy improves survival indubitably in osteosarcoma; nevertheless, the concern is the stagnant progress since the last several decades. There are a handful of active agents and unresolved issues, especially in choosing the ideal chemotherapy regimen. The oncology community is in equipoise regarding the position of high-dose methotrexate (HDMTX), mandatory or adjunct. The choice of therapy becomes widely relevant, including in low- and middle-income countries (LMIC), where HDMTX administration brings additional complexities. Research into novel non-HDMTX-based protocols adapted to the available resources is pivotal in improving disease outcomes, especially in LMIC. The current review focuses on real-world challenges in decision-making and provides a comprehensive overview of the evolution of treatment protocols in LMIC.

Original languageEnglish
Article numbere29540
JournalPediatric Blood and Cancer
Volume69
Issue number3
DOIs
Publication statusPublished - 03-2022

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

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