TY - JOUR
T1 - Responsive Nano-structured Cubosomes
T2 - Advancements and Therapeutic Applications
AU - Miranda, Ishal
AU - Misra, Biyas
AU - Manjunath, Manasa Chikballapur
AU - Nayak, Geetha
AU - Likhitha, Ullal
AU - Nayak, Usha Yogendra
N1 - Publisher Copyright:
© 2025 The Author (s).
PY - 2025
Y1 - 2025
N2 - Nanotechnology has revolutionized drug delivery, which offers innovative ways to maximize treatment efficacy while decreasing side effects. The lyotropic liquid crystalline nanoparticles (LLCNP), such as cubosomes and hexosomes, have gained substantial interest because of their distinctive molecular arrangements. Lipophilic, hydrophilic, and amphiphilic drugs can be encapsulated by cubosomes, making them versatile carriers in drug delivery systems. Different types of cubosomes, such as pH-responsive, temperature-responsive, light-responsive, enzyme-responsive, and multi-stimuli-responsive, have been discussed in this review detailing their preparation methods and therapeutic applications. Cubosomes possess high surface area, are biocompatible, and provide enhanced drug protection. However, formulation stability and scalability are the main challenges. This paper highlights the potential of cubosomes for targeted drug delivery, focusing on their ability to optimize bioavailability and controlled drug release.
AB - Nanotechnology has revolutionized drug delivery, which offers innovative ways to maximize treatment efficacy while decreasing side effects. The lyotropic liquid crystalline nanoparticles (LLCNP), such as cubosomes and hexosomes, have gained substantial interest because of their distinctive molecular arrangements. Lipophilic, hydrophilic, and amphiphilic drugs can be encapsulated by cubosomes, making them versatile carriers in drug delivery systems. Different types of cubosomes, such as pH-responsive, temperature-responsive, light-responsive, enzyme-responsive, and multi-stimuli-responsive, have been discussed in this review detailing their preparation methods and therapeutic applications. Cubosomes possess high surface area, are biocompatible, and provide enhanced drug protection. However, formulation stability and scalability are the main challenges. This paper highlights the potential of cubosomes for targeted drug delivery, focusing on their ability to optimize bioavailability and controlled drug release.
UR - https://www.scopus.com/pages/publications/105012992223
UR - https://www.scopus.com/pages/publications/105012992223#tab=citedBy
U2 - 10.34172/apb.025.43330
DO - 10.34172/apb.025.43330
M3 - Review article
AN - SCOPUS:105012992223
SN - 2228-5881
VL - 15
SP - 284
EP - 292
JO - Advanced Pharmaceutical Bulletin
JF - Advanced Pharmaceutical Bulletin
IS - 2
ER -