TY - JOUR
T1 - Revisiting the Pharmacological Potential of 3-Hydroxyflavone Derivatives (3HF) in Transdermal Drug Delivery by Electrospun Cellulose Acetate Nanofiber
AU - Dayananda, B. Sesappa
AU - Sarojini, B. Kunhanna
AU - Harshitha, K. Ramachandra
AU - Sravani, A. Boyina
AU - Lewis, S.
N1 - Funding Information:
The authors thank DST–PURSE and NMR instrumentation facility, Mangalore University, Mangalore, for assisting in the characterization. The authors also thank Yenapoya Research Centre, Yenapoya (Deemed to be University), Mangalore, for performing biological activity studies of the synthesized compounds. One of the authors K. R. Harshitha acknowledges JRF under the project UGC-CPEPA [2-7/2016 (NS/PE)].
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023/4/5
Y1 - 2023/4/5
N2 - The unexplored anti-inflammatory and wound-scratching assay of 3-hydroxy-2-(2,5-dimethoxyphenyl)-4H-chromen-4-one [3HF(B)] was reported for the first time with the subsequent transdermal drug delivery en route electrospun cellulose acetate nanofiber mat. The higher anti-inflammatory activity of 3HF(B) was revealed by in vitro protein denaturation assay in comparison to Ibuprofen. The wound scratching assay on NIH3T3 cells disclosed the rapid wound healing potential of 3HF(B) in 18 h. The fabricated cellulose acetate nanofiber‘s drug encapsulation efficiency was 82.0±1.0 % whereas drug release ability was 91.29±0.3 % at pH 7.4. The initial rapid release of 37.82±1.3 % of the drug was found to be beneficial for quick recovery from the critical phase of symptoms. These results suggest that the cellulose acetate/3HF(B) composite nanofiber's suitability to be employed as a patch in the transdermal drug delivery system with synergetic anti-inflammatory activity.
AB - The unexplored anti-inflammatory and wound-scratching assay of 3-hydroxy-2-(2,5-dimethoxyphenyl)-4H-chromen-4-one [3HF(B)] was reported for the first time with the subsequent transdermal drug delivery en route electrospun cellulose acetate nanofiber mat. The higher anti-inflammatory activity of 3HF(B) was revealed by in vitro protein denaturation assay in comparison to Ibuprofen. The wound scratching assay on NIH3T3 cells disclosed the rapid wound healing potential of 3HF(B) in 18 h. The fabricated cellulose acetate nanofiber‘s drug encapsulation efficiency was 82.0±1.0 % whereas drug release ability was 91.29±0.3 % at pH 7.4. The initial rapid release of 37.82±1.3 % of the drug was found to be beneficial for quick recovery from the critical phase of symptoms. These results suggest that the cellulose acetate/3HF(B) composite nanofiber's suitability to be employed as a patch in the transdermal drug delivery system with synergetic anti-inflammatory activity.
UR - https://www.scopus.com/pages/publications/85153043194
UR - https://www.scopus.com/inward/citedby.url?scp=85153043194&partnerID=8YFLogxK
U2 - 10.1002/slct.202202702
DO - 10.1002/slct.202202702
M3 - Article
AN - SCOPUS:85153043194
SN - 2365-6549
VL - 8
JO - ChemistrySelect
JF - ChemistrySelect
IS - 13
M1 - e202202702
ER -