TY - JOUR
T1 - Risk of cognitive decline among patients with dengue virus infection
T2 - a systematic review
AU - Thangavelu, Lakshmi
AU - Abdelwahab, Siddig Ibrahim
AU - Farasani, Abdullah
AU - Ballal, Suhas
AU - Bansal, Pooja
AU - Nathiya, Deepak
AU - Kaur, Kiranjeet
AU - Kumar, M. Ravi
AU - Sinha, Aashna
AU - Alrasheed, Hayam A.
AU - Al-Subaie, Maha F.
AU - Al Kaabi, Nawal A.
AU - Al bshabshe, Ali
AU - Al Fares, Mona A.
AU - Albayat, Hawra
AU - Rabaan, Ali A.
AU - Pant, Kumud
AU - Zahiruddin, Quazi Syed
AU - Rao, Arathi P.
AU - Khatib, Mahalaqua Nazli
AU - Alfaifi, Hassan Ahmad
AU - Mohan, Syam
AU - Sah, Sanjit
AU - Satapathy, Prakasini
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of CINP.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion. This systematic review followed preferred reporting items for systematic reviews and meta-analyses guidelines. A comprehensive literature search was conducted in PubMed, EMBASE, and Web of Science up to January 18, 2024. Studies examining the prevalence and association of cognitive impairments in dengue patients were included. Data extraction and quality assessment were performed using Nested Knowledge software and the Newcastle-Ottawa Scale. Of the 1129 articles identified, 5 were included in the review, covering a total of 200 873 participants from Taiwan, Brazil, and France. Evidence from population-based cohort studies indicated short-term cognitive impairments, including confusion and memory loss, in some dengue patients. Additionally, long-term risks of dementia, including Alzheimer disease and vascular dementia, were observed, particularly among older adults. Although the findings suggest there might be an association between dengue infection and cognitive decline, the mechanisms underlying this link remain unclear. This systematic review suggests that dengue virus infection may affect cognitive function in both acute and long-term contexts. However, the current evidence is not strong enough to establish a conclusive link. Further research with larger sample sizes and longitudinal studies is essential to confirm the impact of dengue virus on cognitive health.
AB - Dengue fever, caused by the dengue virus and transmitted through Aedes mosquitoes, is a growing public health concern, particularly in tropical and subtropical regions. Traditionally associated with febrile and hemorrhagic symptoms, recent research suggests a potential link between dengue and cognitive impairments. This systematic review assessed existing research to understand the association between dengue virus infection and cognitive impairments, including dementia, Alzheimer disease, memory loss, and confusion. This systematic review followed preferred reporting items for systematic reviews and meta-analyses guidelines. A comprehensive literature search was conducted in PubMed, EMBASE, and Web of Science up to January 18, 2024. Studies examining the prevalence and association of cognitive impairments in dengue patients were included. Data extraction and quality assessment were performed using Nested Knowledge software and the Newcastle-Ottawa Scale. Of the 1129 articles identified, 5 were included in the review, covering a total of 200 873 participants from Taiwan, Brazil, and France. Evidence from population-based cohort studies indicated short-term cognitive impairments, including confusion and memory loss, in some dengue patients. Additionally, long-term risks of dementia, including Alzheimer disease and vascular dementia, were observed, particularly among older adults. Although the findings suggest there might be an association between dengue infection and cognitive decline, the mechanisms underlying this link remain unclear. This systematic review suggests that dengue virus infection may affect cognitive function in both acute and long-term contexts. However, the current evidence is not strong enough to establish a conclusive link. Further research with larger sample sizes and longitudinal studies is essential to confirm the impact of dengue virus on cognitive health.
UR - https://www.scopus.com/pages/publications/85212457408
UR - https://www.scopus.com/pages/publications/85212457408#tab=citedBy
U2 - 10.1093/ijnp/pyae053
DO - 10.1093/ijnp/pyae053
M3 - Review article
C2 - 39487786
AN - SCOPUS:85212457408
SN - 1461-1457
VL - 27
JO - International Journal of Neuropsychopharmacology
JF - International Journal of Neuropsychopharmacology
IS - 12
M1 - pyae053
ER -
