Role of interleukin-22 in tuberculosis patients

Shruti Gupta, Mithu Banerjee, Kavya Gauba, Prasenjit Mitra, Jyoti Shekhawat, Nishant Chauhan, Hemant Borana, Mahadev Rao, Dharmveer Yadav, Praveen Sharma

Research output: Contribution to journalArticlepeer-review


Objectives: Disease progression of tuberculosis (TB) depends on the balance between the microorganism's virulence and the host defense systems (mainly T cell-mediated immune response). Interleukin-22 (IL-22) helps in cell proliferation and regeneration and provides protection against microbial diseases. The IL-22-producing T cells can migrate into the granulomas during TB infection. However, disparity exists in literature regarding its role. The present study aims to compare serum IL-22 levels and its' expression in TB patients and healthy controls. Methods: 87 TB patients and 85 healthy subjects were enrolled in the study. Under aseptic conditions, venous blood was withdrawn. Serum IL-22 levels were estimated using enzyme-linked immunosorbent assay, and its gene expression was assessed using SYBR green-based quantitative PCR technology. A statistical analysis was performed using SPSS. Results: The median (interquartile range) of serum IL-22 levels was significantly lower in TB patients (18.55 (5.08) pg/mL) when compared to controls (49.38 (162.88) pg/mL) (p<0.0001). The IL-22 expression was significantly upregulated with a fold change value of 29.44 in TB patients. Conclusions: The IL-22 levels were found to be significantly decreased in patients, contradictory to its expression, which is upregulated. It plays a crucial role for the modulation of tissues in response to TB infection.

Original languageEnglish
Pages (from-to)83-89
Number of pages7
JournalJournal of Basic and Clinical Physiology and Pharmacology
Issue number1
Publication statusPublished - 01-01-2023

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Drug Discovery


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