Role of miRNA clusters in epithelial to mesenchymal transition in cancer

Vaibhav Shukla; Divya Adiga; Padacherri Vethil Jishnu; Vinay Koshy Varghese; Kapaettu Satyamoorthy; Shama Prasada Kabekkodu

doi:10.2741/e857

Role of miRNA clusters in epithelial to mesenchymal transition in cancer

Vaibhav Shukla, Divya Adiga, Padacherri Vethil Jishnu, Vinay Koshy Varghese, Kapaettu Satyamoorthy, Shama Prasada Kabekkodu

Technology, Information, Forecasting and Assessment Council - Centre of Relevance and Excellence (TIFAC-CORE) in Pharmacogenomics
Manipal School of Life Sciences, Manipal
Department of Cell and Molecular Biology, Manipal School of Life Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

Original language	English
Pages (from-to)	48-78
Number of pages	31
Journal	Frontiers in bioscience (Elite edition)
Volume	12
DOIs	https://doi.org/10.2741/e857
Publication status	Published - 01-01-2020

All Science Journal Classification (ASJC) codes

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2741/e857

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title = "Role of miRNA clusters in epithelial to mesenchymal transition in cancer",

abstract = "Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.",

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AU - Shukla, Vaibhav

AU - Adiga, Divya

AU - Jishnu, Padacherri Vethil

AU - Varghese, Vinay Koshy

AU - Satyamoorthy, Kapaettu

AU - Kabekkodu, Shama Prasada

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AB - Epithelial to mesenchymal transition (EMT) is a multistep biological process in which epithelial cells acquire characteristics of mesenchymal cells. Inappropriate activation of EMT contributes to the acquisition of pro-metastatic characteristics and cancer progression. EMT process involves the downregulation of epithelial markers (EpCAM, CDH1) and upregulation of mesenchymal markers (VIM, CDH2) and EMT-transcription factors (ZEB1/2, TWIST1/2, SNAI1, SLUG). MicroRNAs, a class of non-coding RNA post-transcriptionally govern gene expression by binding to the target mRNAs. A large proportion of miRNAs occur as miRNA clusters consisting of two or more miRNA coding genes. MiRNA clusters are reported to regulate diverse biological functions, including EMT. This comprehensive review discusses the role of miRNA clusters in EMT.

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Role of miRNA clusters in epithelial to mesenchymal transition in cancer

Abstract

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