Role of novel biomarker monocyte chemo-attractant protein-1 in early diagnosis & predicting progression of diabetic kidney disease: A comprehensive review

Shilna Muttickal Swaminathan, Indu Ramachandra Rao, Mohan V. Bhojaraja, Ravindra Prabhu Attur, Shivashankara Kaniyoor Nagri, Dharshan Rangaswamy, Srinivas Vinayak Shenoy, Shankar Prasad Nagaraju

Research output: Contribution to journalReview articlepeer-review

Abstract

Diabetic kidney disease (DKD) is the most devastating complication of diabetes mellitus. Identification of patients at the early stages of progression may reduce the disease burden. The limitation of conventional markers such as serum creatinine and proteinuria intensify the need for novel biomarkers. The traditional paradigm of DKD pathogenesis has expanded to the activation of the immune system and inflammatory pathways. Monocyte chemo-attractant protein-1 (MCP-1) is extensively studied, as a key inflammatory mediator that modulates the development of DKD. Recent evidence supports the diagnostic role of MCP-1 in patients with or without proteinuria in DKD, as well as a significant role in the early prediction and risk stratification of DKD. In this review, we will summarize and update present evidence for MCP-1 for diagnostic ability and predicting the progression of DKD.

Original languageEnglish
Pages (from-to)33-44
Number of pages12
JournalJournal of the National Medical Association
Volume116
Issue number1
DOIs
Publication statusPublished - 02-2024

All Science Journal Classification (ASJC) codes

  • General Medicine

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