TY - JOUR
T1 - Role of Statins in New-onset Diabetes Mellitus
T2 - The Underlying Cause, Mechanisms Involved, and Strategies to Combat
AU - Keni, Raghuvir
AU - Sekhar, Abinitha
AU - Gourishetti, Karthik
AU - Nayak, Pawan G.
AU - Kinra, Manas
AU - Kumar, Nitesh
AU - Shenoy, Rekha R.
AU - Kishore, Anoop
AU - Nandakumar, Krishnadas
N1 - Publisher Copyright:
Copyright© Bentham Science Publishers; For any queries, please email at [email protected].
PY - 2021
Y1 - 2021
N2 - Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in patients with diabetes. A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on the recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition.
AB - Statins have transformed the treatment of cardiovascular diseases through primary and secondary prevention of events. Despite the success of statin's management of cardiovascular conditions, certain clinical trials, reviews, and meta-analysis point out that statins have the propensity to induce diabetes. The risk further increases with intensive statin therapy or in patients with diabetes. A proper mechanism for the induction of the diabetic condition has not yet been determined. The involvement of statin with beta cells in insulin secretion and peripheral cells in insulin resistance has been widely studied and established. The present review provides an update on the recent understanding of statin-induced diabetes. This covers the origin of statins, their development, possible mechanisms that explain the adverse effects in glucose homeostasis, and probable targets to remedy the condition.
UR - http://www.scopus.com/inward/record.url?scp=85112124960&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85112124960&partnerID=8YFLogxK
U2 - 10.2174/1389450122666210120125945
DO - 10.2174/1389450122666210120125945
M3 - Article
C2 - 33494673
AN - SCOPUS:85112124960
SN - 1389-4501
VL - 22
SP - 1121
EP - 1128
JO - Current Drug Targets
JF - Current Drug Targets
IS - 10
ER -
