Role of stem cells in diabetes, liver disease, and cancer treatment

Rajamanikkam Kamaraj, Mohammad Javad Mehran, Harshita Tiwari, Monu Kumar Shukla, Mehmet Veysi Cetiz, Zarrin Basharat, Rambod Barzigar, Sana Jalili, Petr Pávek, Ranjith Kumavath, Manash K. Paul, Khawaja Husnain Haider, Sayan Paul*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Over the past century, humankind has made remarkable strides in knowledge and technology. One of the most exciting areas of advancement is in stem cell research, where we can create artificial intelligence that is difficult to distinguish from a live human being, launch rockets into space, use computers that can store terabytes of data and process billions of instructions per second, and create smartphones that can send and receive dozens of megabytes of data per second between far-flung locations on Earth. Despite these significant advancements, there are still many disorders that have no known treatments, and sometimes, we are even unable to determine the underlying cause of the illness. There are two alternative techniques for treating every given illness condition. For most patients, the most common accessible treatment choices are those that reduce or inhibit the state of illness. This kind of therapy is frequently administered as chemical or biological medications, either with or without surgery. The second treatment strategy aims to return the pathogenic environment to its initial or normal condition. This second, uncommon alternative is only appropriate for a few disorders for which medication is ineffective in healing the damage and cannot regenerate or restore the injured tissue's or organ's normal function. Organ transplantation and stem cell treatment are two significant ways regenerative medicine is used. Stem cell therapy, with its immunomodulatory activities, multilineage differentiation capabilities, and regeneration potential, represents a new and promising mode of treatment for diabetes, liver diseases, and cancer. In the context of diabetes, stem cells play a crucial role in regenerating functional insulin-producing cells; in liver disease, they aid in regenerating hepatocyte-like cells; and in cancer, they have the potential to target and destroy cancerous cells. Several types of stem cells, including induced pluripotent, embryonic, and adult stem cells, have been tested for their ability to regenerate these functional cells. In conclusion, the potential of stem cell therapy in treating terminal illnesses, including diabetes, liver disease, and different types of cancer treatments, is yet to be fully realized and holds the greatest hope for the future.

Original languageEnglish
Title of host publicationHandbook of Regenerative Medicine
Subtitle of host publicationStem Cell-based Approach
PublisherCRC Press
Pages404-420
Number of pages17
ISBN (Electronic)9781040339886
ISBN (Print)9781032735191
DOIs
Publication statusPublished - 03-07-2025

All Science Journal Classification (ASJC) codes

  • General Medicine
  • General Immunology and Microbiology
  • General Nursing
  • General Biochemistry,Genetics and Molecular Biology
  • General Pharmacology, Toxicology and Pharmaceutics

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