Role of tigecycline in the treatment of urinary tract infections: a systematic review of published case reports

Reema Charles, Shreya Das Adhikari, Ankit Mittal, Souvik Chaudhuri, Mukund Gupta, Wasim Khot, Marco Schito, Nitin Gupta

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Introduction: The emergence of multi-drug resistance has forced clinicians to occasionally use drugs that are not approved to treat urinary tract infections (UTIs). This systematic review aimed to evaluate the utility of tigecycline in patients with UTIs. Methodology: A systematic review of case studies was used to retrieve articles between 1.1.1999 to 1.1.2021 from two databases, PubMed and Embase. The ti-tle-abstract screening was done for 198 articles, out of which 69 articles were included for full-text screening. A total of 18 articles with 27 cases were included for final analysis. Results: Of the 27 cases, there were 13 cases with complicated UTI and five had catheter-associated UTI. The most common organisms were Klebsiella pneumoniae (n=11), Acinetobacter baumannii (n=9), and Escherichia coli (n=6). Tigecycline was used as monotherapy in 19 patients and as a combination therapy in 8 patients. The median duration of tigecycline was 13 (10-15) days. A favourable clinical or microbiological response at varying intervals was seen in 24/27 (88.9%). Within three months of a favourable response, recurrence of symptoms was seen in four patients. Conclusion: In a small analysis of published case re-ports, tigecycline appeared to be a relatively effective treatment in patients with UTIs, caused by multid-rug-resistant organisms. Where tigecycline is the only susceptible drug, it can be used for treatment. Further research, such as randomized controlled trials, is need-ed to fully assess the drug’s efficacy in this context.

Original languageEnglish
Pages (from-to)516-524
Number of pages9
JournalInfezioni in Medicina
Volume30
Issue number4
DOIs
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Infectious Diseases

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