Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells

S. A. Salmataj; Pushpanjali Bhat; Shobha Kamath

doi:10.18311/ti/2020/v27i3&4/26077

Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells

S. A. Salmataj
, Pushpanjali Bhat
, Shobha Kamath^*

^*Corresponding author for this work

Department of Biochemistry, Kasturba Medical College, Manipal

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured

Original language	English
Pages (from-to)	188-192
Number of pages	5
Journal	Toxicology International
Volume	27
Issue number	3
DOIs	https://doi.org/10.18311/ti/2020/v27i3&4/26077
Publication status	Published - 07-2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Toxicology
Health, Toxicology and Mutagenesis

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10.18311/ti/2020/v27i3&4/26077

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title = "Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells",

abstract = "The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured",

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AU - Salmataj, S. A.

AU - Bhat, Pushpanjali

AU - Kamath, Shobha

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AB - The potential role of oxidative stress in the pathogenesis induced by arsenic proposes that antioxidants can be deliberated as an alternative approach in alleviating arsenic-induced toxicity. The aim of this work was to assay in vitro the potential advantageous effects of plant flavonoid rutin against arsenate exposure, by studying lipid peroxidation and the stress-related markers. Rutin, a flavanol, has been exhibiting anti-cancer property, mitigating, hostile to diabetic and anti-inflammatory properties. CHO cells were selected to study the effect of sodiumarsenate and its amelioration by rutin a citrus flavonoid glycoside. Sodium arsenate at low concentration induced cytotoxicity and genotoxicity. MTT assay, Catalase, Superoxide dismutase, GSH, GST and lipid peroxidation was measured in CHO cell. Pre-treatment of CHO cells with rutin attenuated arsenate induced toxicity. DNA damage was also measured

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Rutin a citrus flavonoid attenuates sodium arsenate induced cytotoxicity in CHO cells

Abstract

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