TY - JOUR
T1 - Screening of mitochondrial mutations and insertion-deletion polymorphism in gestational diabetes mellitus in the Asian Indian population
AU - Khan, Imran Ali
AU - Shaik, Noor Ahmad
AU - Pasupuleti, Nagarjuna
AU - Chava, Srinivas
AU - Jahan, Parveen
AU - Hasan, Qurratulain
AU - Rao, Pragna
N1 - Funding Information:
We are thankful to all the volunteers who have participated in this study. We are thankful to the Department of gynecology and obstetrics, Kamineni hospitals and Muslim maternity hospitals for helping with the samples. We are thankful to the Indian Council for Medical Research for the funding of this research (Sanction no. 5-3-8-39-2007 ; RHN).
Publisher Copyright:
© 2014. Production and hosting by Elsevier B.V.
PY - 2015
Y1 - 2015
N2 - In this study we scrutinized the association between the A8344G/A3243G mutations and a 9-bp deletion polymorphism with gestational diabetes mellitus (GDM) in an Asian Indian population. The A3243G mutation in the mitochondrial tRNALeu(UUR) causes mitochondrial encephalopathy myopathy, lactic acidosis, and stroke-like episodes (MELAS), while the A8344G mutation in tRNALys causes myoclonus epilepsy with ragged red fibers (MERRF). We screened 140 pregnant women diagnosed with GDM and 140 non-GDM participants for these mutations by PCR-RFLP analysis. Both A3243G and A8344G were associated with GDM (A3243: OR-3.667, 95% CI=1.001-13.43, p=0.03; A8344G: OR-11.00, 95% CI=0.6026-200.8, p=0.04). Mitochondrial DNA mutations contribute to the development of GDM. Our results conclude that mitochondrial mutations are associated with the GDM women in our population. Thus it is important to screen other mitochondrial mutations in the GDM women.
AB - In this study we scrutinized the association between the A8344G/A3243G mutations and a 9-bp deletion polymorphism with gestational diabetes mellitus (GDM) in an Asian Indian population. The A3243G mutation in the mitochondrial tRNALeu(UUR) causes mitochondrial encephalopathy myopathy, lactic acidosis, and stroke-like episodes (MELAS), while the A8344G mutation in tRNALys causes myoclonus epilepsy with ragged red fibers (MERRF). We screened 140 pregnant women diagnosed with GDM and 140 non-GDM participants for these mutations by PCR-RFLP analysis. Both A3243G and A8344G were associated with GDM (A3243: OR-3.667, 95% CI=1.001-13.43, p=0.03; A8344G: OR-11.00, 95% CI=0.6026-200.8, p=0.04). Mitochondrial DNA mutations contribute to the development of GDM. Our results conclude that mitochondrial mutations are associated with the GDM women in our population. Thus it is important to screen other mitochondrial mutations in the GDM women.
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U2 - 10.1016/j.sjbs.2014.11.001
DO - 10.1016/j.sjbs.2014.11.001
M3 - Article
AN - SCOPUS:85027941536
SN - 1319-562X
VL - 22
SP - 243
EP - 248
JO - Saudi Journal of Biological Sciences
JF - Saudi Journal of Biological Sciences
IS - 3
ER -