Segmentation of Glioblastoma Multiforme from MR Images - A comprehensive review

Delineation of active tumor region and perifocal edema from Magnetic Resonance (MR) images of Glioblastoma Multiforme (GBM) is difficult as GBM is highly infiltrating and non-enhancing on imagery. The segmentation becomes challenging when the tissue classes in the perifocal region, such as White Matter (WM) and edema, similarly, necrosis and Gray Matter (GM) are homogenous in intensity and texture. Precise delineation of GBM-focus and perifocal edema is mandatory for surgical and Radio Therapy (RT) planning and for the evaluation of tumor progress and efficiency of treatment. This article is a comprehensive review on techniques used for the segmentation of GBM from MR images.