TY - JOUR
T1 - Serum biomarkers to predict risk of testicular and penile cancer in AMORIS
AU - Ghoshal, Arunangshu
AU - Garmo, Hans
AU - Arthur, Rhonda
AU - Hammar, Niklas
AU - Jungner, Ingmar
AU - Malmström, Håkan
AU - Lambe, Mats
AU - Walldius, Göran
AU - Van Hemelrijck, Mieke
N1 - Publisher Copyright:
© the authors
PY - 2017/8/23
Y1 - 2017/8/23
N2 - Purpose: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Materials and methods: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models. Results: A total of 125 men were diagnosed with testicular cancer and 50 with penile cancer during a mean follow-up of 20.3 years. No statistically significant trends were seen between serum inflammatory markers and risk of penile cancer, but higher albumin levels increased the risk of testicular cancer [HR for albumin (g/L): 1.10 (95% CI: 1.03–1.18)]. However, this trend was not observed when using medical cut-offs of albumin. Conclusions: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies.
AB - Purpose: To evaluate the association between commonly measured serum biomarkers of inflammation and penile and testicular cancer risk in the Swedish Apolipoprotein-related MORtality RISk (AMORIS) study. Materials and methods: A total of 205,717 subjects had baseline measurements of C-reactive protein, albumin, and haptoglobin. The association between quartiles and dichotomised values of inflammatory markers and penile and testicular cancer risk were analysed by using multivariate Cox proportional hazard models. Results: A total of 125 men were diagnosed with testicular cancer and 50 with penile cancer during a mean follow-up of 20.3 years. No statistically significant trends were seen between serum inflammatory markers and risk of penile cancer, but higher albumin levels increased the risk of testicular cancer [HR for albumin (g/L): 1.10 (95% CI: 1.03–1.18)]. However, this trend was not observed when using medical cut-offs of albumin. Conclusions: In the present study, we did not find support for an association between commonly used markers of inflammation and risk of testicular or penile cancer. The role of inflammation may be more complicated and require assessment of more specialised measurements of inflammation in future studies.
UR - https://www.scopus.com/pages/publications/85030236279
UR - https://www.scopus.com/inward/citedby.url?scp=85030236279&partnerID=8YFLogxK
U2 - 10.3332/ecancer.2017.762
DO - 10.3332/ecancer.2017.762
M3 - Article
AN - SCOPUS:85030236279
SN - 1754-6605
VL - 11
JO - ecancermedicalscience
JF - ecancermedicalscience
M1 - 762
ER -
