Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein

Shivananda B. Nayak; S. Yashwanth; Sneha M. Pinto; Vinutha R. Bhat; Srimathi S. Mayya

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein

Shivananda B. Nayak^*, S. Yashwanth, Sneha M. Pinto, Vinutha R. Bhat, Srimathi S. Mayya

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Indian Journal of Physiology and Pharmacology
Volume	49
Issue number	3
Publication status	Published - 07-2005

All Science Journal Classification (ASJC) codes

Physiology
Pharmacology
Physiology (medical)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{28a98c81dfd84345b7a2d79ea5ceda31,

title = "Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein",

abstract = "Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.",

author = "Nayak, {Shivananda B.} and S. Yashwanth and Pinto, {Sneha M.} and Bhat, {Vinutha R.} and Mayya, {Srimathi S.}",

year = "2005",

month = jul,

language = "English",

volume = "49",

pages = "341--344",

journal = "Indian Journal of Physiology and Pharmacology",

issn = "0019-5499",

publisher = "Scientific Scholar",

number = "3",

}

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein. / Nayak, Shivananda B.; Yashwanth, S.; Pinto, Sneha M. et al.
In: Indian Journal of Physiology and Pharmacology, Vol. 49, No. 3, 07.2005, p. 341-344.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein

AU - Nayak, Shivananda B.

AU - Yashwanth, S.

AU - Pinto, Sneha M.

AU - Bhat, Vinutha R.

AU - Mayya, Srimathi S.

PY - 2005/7

Y1 - 2005/7

N2 - Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.

AB - Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substances (TEARS) were estimated in 25 patients of liver cancer. The copper to ceruloplasmin ratio was moderately increased (P<0.05) but the copper (P<0.001) and ceruloplasmin (P<0.001) levels were significantly increased in liver cancer patients when compared to controls. Protein thiols levels were found to be highly significant (P<0.001). Where as the TEARS levels were not found to be significant. Trace elements and free radicals have been implicated in the etiology of cancer. Hence the estimation of ceruloplasmin and protein thiols along with the copper may be of high value in the early diagnosis of cancer.

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M3 - Article

C2 - 16440854

AN - SCOPUS:23044451707

SN - 0019-5499

VL - 49

SP - 341

EP - 344

JO - Indian Journal of Physiology and Pharmacology

JF - Indian Journal of Physiology and Pharmacology

IS - 3

ER -

Serum copper, ceruloplasmin, protein thiols and thiobarbituric acid reactive substance status in liver cancer associated with elevated levels of alfa-fetoprotein

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

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