Serum High Mobility Group Box1 Protein and Toll-like Receptor 4 Correlation with Lipid Profile in Patients with Non-alcoholic Fatty Liver Disease

Bharateesh H. Yadav, Poornima Ajay Manjrekar, Anupama Hegde, Santhosh Rai, Sindhu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: HMGB1 (high mobility group box1 protein) extracellularly acts as a cytokine in response to free fatty acids (FFA) infusion to the liver in which TLR4 (toll-like receptor4) is a receptor for HMGB1 to generate the inflammatory response and it is responsible for the emergence of Non-alcoholic fatty liver disease (NAFLD). This study aimed to correlate the HMGB1 and TLR4 with lipid profile in NAFLD patients with dyslipidemia. Methods: This prospective study included NAFLD patients with dyslipidemia (n=87) with a mean age of 50.5±6.25, of which 54 were males and 33 were females. Data for the lipid profile and liver enzyme parameters except HMGB1 and TLR4 were collected from the data management system of the central laboratory. HMGB1 and TLR4 values were estimated by enzyme-linked immunosorbent assay (ELISA) method, statistically Karl Pearson’s, spearmen’s correlation and Independent t-test, Mann-Whitney U-test were applied to find the correlation and comparison of HMGB1 and TLR4 with lipid profile and liver enzymes based on the age group and gender respectively. Results: No correlation was observed with the HMGB1 and TLR4 with lipid profile in NAFLD patients. Additionally, it was noted that the comparison study of AST/ALT ratio with gender showed a significant difference but not with HMGB1 and TLR4. Conclusion: Males were affected earlier than females. The study group had significantly higher levels of LDL-cholesterol as against the treatment goals. Levels of extracellular HMGB1, which is a damage-associated molecular pattern (DAMP) were found to be elevated, similar to the findings with TLR4 levels which act as a receptor for HMGB1. However, we did not find a correlation of HMGB1 and TLR4 with lipid profile in non-alcoholic fatty liver disease.

Original languageEnglish
Pages (from-to)1042-1050
Number of pages9
JournalUniversal Journal of Public Health
Volume12
Issue number6
DOIs
Publication statusPublished - 12-2024

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Medicine (miscellaneous)
  • Health Professions (miscellaneous)
  • Health Policy
  • Public Health, Environmental and Occupational Health

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