Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: Case of cervical and oral cancers

Gopal Karemore; Sujatha Sujatha; Lavanya Rai; Keerthilatha M. Pai; V. B. Kartha; C. Santhosh

doi:10.1117/12.809930

Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: Case of cervical and oral cancers

Gopal Karemore^*, Sujatha, Lavanya Rai, Keerthilatha M. Pai, V. B. Kartha, C. Santhosh

^*Corresponding author for this work

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Abstract

The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.

Original language	English
Article number	71820J
Journal	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	7182
DOIs	https://doi.org/10.1117/12.809930
Publication status	Published - 01-06-2009
Event	Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues VII - San Jose, CA, United States Duration: 26-01-2009 → 28-01-2009

All Science Journal Classification (ASJC) codes

Applied Mathematics
Computer Science Applications
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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abstract = "The serum protein profiles of normal subjects, patients diagnosed with cervical cancer, and oral cancer were recorded using High Performance Liquid Chromatography combined with Laser Induced Fluorescence detection (HPLC-LIF). Serum protein profiles of the above three classes were tested for establishing the ability of HPLC-LIF protein profiling technique for discrimination, using hard clustering and Fuzzy clustering methods. The clustering algorithms have quite successfully classified the profiles as belonging to normal, cancer of cervix, and oral cancer conditions.",

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Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: Case of cervical and oral cancers. / Karemore, Gopal; Sujatha; Rai, Lavanya et al.
In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 7182, 71820J, 01.06.2009.

Research output: Contribution to journal › Article › peer-review

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AU - Karemore, Gopal

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AU - Santhosh, C.

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Serum protein profile study of clinical samples using high performance liquid chromatography-laser induced fluorescence: Case of cervical and oral cancers

Abstract

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