Sesamol protects MIN6 pancreatic beta cells against simvastatin-induced toxicity by restoring mitochondrial membrane potentials

Agriculture & Biology

• islets of Langerhans 66%
• mitochondrial membrane 58%
• membrane potential 55%
• toxicity 37%
• protective effect 26%
• cell cycle checkpoints 24%
• pretreatment 20%
• cells 17%
• inhibitory concentration 50 15%
• hyperlipidemia 11%
• insulin resistance 11%
• hypoglycemic agents 11%
• diabetes 9%
• dosage 9%
• drug therapy 9%
• interphase 8%
• cell cycle 8%
• antioxidants 5%
• mice 5%
• assays 4%

Medicine & Life Sciences

• sesamol 100%
• Simvastatin 65%
• Insulin-Secreting Cells 59%
• Mitochondrial Membrane Potential 58%
• Cell Cycle Checkpoints 10%
• Inhibitory Concentration 50 10%
• Insulinoma 6%
• Cell Cycle Resting Phase 6%
• G1 Phase 5%
• Dyslipidemias 5%
• Hydroxymethylglutaryl-CoA Reductase Inhibitors 5%
• Hypoglycemic Agents 5%
• Insulin Resistance 4%
• Cell Cycle 4%
• Poisons 4%
• Antioxidants 4%
• Cell Membrane 4%
• In Vitro Techniques 2%
• Pharmaceutical Preparations 2%

Earth & Environmental Sciences

• toxicity 40%
• membrane 37%
• cell 34%
• dose 8%
• diabetes 6%
• antioxidant 5%
• toxic effect 5%
• assay 4%
• incubation 4%
• drug 4%
• effect 3%
• loss 2%