@article{2115c0342d384f68806aaaf20a561b3b,
title = "Simultaneous derivative spectrophotometric estimation of aceclofenac and tramadol with paracetamol in combination solid dosage forms",
abstract = "A derivative spectrophotometric procedure has been developed for the simultaneous determination of individual combination of aceclofenac and tramadol with paracetamol in combined tablet preparation. Tablet extracts of the drugs were prepared in distilled water. The zero crossing point technique and the compensation technique were used to estimate the amount of each drug in the combined formulations, and were compared. The results were found to be accurate and free from interferences. The procedure is rapid, simple, nondestructive, and does not require solutions of equations. Calibration graphs are linear (r=0.9999), with a zero intercept up to 24 mg/ml of each drug in combination with paracetamol. Detection limits at the p = 0.05 level of significance were calculated to be 0.5 mg/ml of aceclofenac, tramadol and paracetamol respectively.",
author = "K. Srinivasan and J. Alex and A. Shirwaikar and S. Jacob and {Sunil Kumar}, M. and S. Prabu",
note = "Cited By :28 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Srinivasan, K.; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, MAHE, Manipal - 576104, India; email: pansrini@yahoo.co.in Chemicals/CAS: aceclofenac, 89796-99-6; paracetamol, 103-90-2; tramadol, 27203-92-5, 36282-47-0 References: Fell, A.F., Smith, G., Principles of Derivative Spectrophotometry (1982) Anal Proc, 19, pp. 28-32; O'Haver, T.C., Green, G.L., Derivative Spectrophotometry and its Applications (1976) Anal Chem, 48, pp. 312-315; Morelli, B., Determination of a Quaternary Mixture of Vitamins B6, B1, and B12 by Derivative Spectrophotometry (1995) J Pharm Sci, 84, pp. 34-37; Morelli, B., Determination of Anafranil in Pharmaceuticals by Difference and Difference-Derivative Spectrophotometry (1996) Anal Lett, 29, pp. 1551-1555; Morelli, B., Determination of Noramidopyrine Methane Sulfonate Sodium Salt, Pitophenone Hydrochloride and Fenpiverine Bromide in Pharmaceuticals by Ratio-Spectra Zero-Crossing Derivative Spectrophotometry (1998) Anal Lett, 31, pp. 2431-2435; Morelli, B., Determination of Mixtures of Cephacetrile and Ceftezole in a Pure form and Injections, by 'Zero- Crossing' Derivative Spectrophotometry (1988) Anal Lett, 21, pp. 43-46; Brogden, R.N., Wiseman, L.R., New non-steroridal anti-inflammatory agent (1996) Drugs, 52, pp. 113-115; Grau, M., Grauch, J.L., Montero, A., Felipe, A., Julia, S., Pharmacology of the potent new non-steroridal anti-inflammatory agent aceclofenac (1991) Arzneim Forsch, 41, pp. 1265-1276; Lee, H.S., Choi, S.J., Jeong, C.K., Simultaneous determination of aceclofenac and diclofenac in human plasma by narrow bore HPLC using Column-switching (2000) J Pharm Biomed Anal, 23, pp. 775-781; Posac, J.R., Vazquez, M.D., Tascon, M.L., Acuna, J.A., Dela, F., Fuente, C., Determination of Aceclofenac Using Adsorptive Stripping Voltammetric Techniques on Conventional and Chemically Modified Carbon Paste Electrodes (1995) Talanta, 42, pp. 293-304; Zawilla, N.H., Abdul, A.M., El-Kousy, N.M., El-Moghazy, A.S., Determination of Aceclofenac in Bulk and Pharmaceutical Formulations (2002) J Pharm Biomed Anal, 27, pp. 243-251; Gutstein HG, Akil H.. Opioid analgesics. In: Hardman JG, Limbird LE, Gilman AG, editors. Goodman and Gillman.s The Pharmacological basis of Therapeutics. 10th ed. McGraw-Hill: London; 2001. p. 569-620; Rang HP, Dale MM, Ritter JM, Moore RK, editors. Antiinflammatory Agents: Rang and Dale's Pharmacology. 5th ed. Church Livingstone: London; 2003. p. 580-5; Meyyanathan, S.N., Pradeep, K., Suresh, B., Analysis of Tramadol in Pharmaceutical Preparations by High Performance Thin Layer Chromatography (2003) J Separation Sci, 26, pp. 1359-1362; Gan, S.H., Ismail, R., Validation of a High Performance Liquid Chromatography Method for Tramadol and O-desmethyltramadol in Human Plasma using Solid-phase Extraction (2001) J Chromatogr B Biomed Sci Appl, 759, pp. 325-335; Ho, S.T., Wan, J.J., Liaw, W.J., Ho, C.M., Li, J.H., Determination of tramadol by capillary gas Chromatography with flame ionization detection. Application to human and rabbit pharmacokinetic studies (1999) J Chromatogr B Biomed Sci Appl, 736, pp. 89-96; Ravisankar, S., Vasudevan, M., Nanjan, M.J., Biju, K., Suresh, B., Reverse Phase HPLC Method for the Estimation of Paracetamol, Chlorzoxazone and Diclofenac Sodium in Formulations (1997) Indian Drugs, 34, pp. 663-665; Erk, N., Ozkar, Y., Banoglu, E., Ozkan, S.A., Senturk, Z., Simultaneous Determination of Paracetamol and Mthocarbamol in Tablets by Ratio Spectra Derivative Spectrophotometry and LC (2001) Pharm Biomed Anal, 24, pp. 469-475; Monser, L., Darghouth, F., Simultaneous LC Determination of Paracetamol and Related Compounds in Pharmaceutical Formulations using a Carbon-based Column (2002) J Pharm Biomed Anal, 27, pp. 851-860; Kartel M. LC Method for the Analysis of Paracetamol, Caffeine and Codeine Phosphate in Pharmaceutical Preparations. J Pharm Biomed Anal 2001;26:857-64UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-36048959814&partnerID=40&md5=2d103829adc4d927d47d907dcfc6ee1f",
year = "2007",
language = "English",
volume = "69",
pages = "540--545",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "4",
}