TY - JOUR
T1 - Sirtuins, a potential target in Traumatic Brain Injury and relevant experimental models
AU - Ranadive, Niraja
AU - Arora, Devinder
AU - Nampoothiri, Madhavan
AU - Mudgal, Jayesh
N1 - Funding Information:
The work was supported by Manipal Academy of Higher Education, Karnataka, India with Intramural Funding ( MCOPS/IMF/2019 ) to JM and Scholarship to NR under Dr TMA Pai Structured PhD programme.
Funding Information:
Authors are thankful to Manipal Academy of Higher Education (MAHE), Karnataka, India for providing funding and infrastructural support to carry out the work. Authors also acknowledge the collaborative efforts between MAHE, India and Griffith University, Australia.
Publisher Copyright:
© 2021 Elsevier Inc.
PY - 2021/6
Y1 - 2021/6
N2 - Traumatic brain injury (TBI) can simply be defined as a violent external injury to the head causing brain dysfunction. The primary injury occurs immediately on impact whereas the secondary injury begins minutes to months after impact. TBI affects a vast majority of population worldwide yet, there isn't any therapeutic intervention available. Sirtuins (SIRTs) are important regulator proteins found in humans. In several neurodegenerative diseases, SIRTs have proven its neuroprotective actions. Owing to the pathophysiological similarities in these diseases and TBI, SIRTs may serve as a potential target for therapeutic intervention in TBI. This review aims to describe the relevance of SIRTs as a potential pharmacological target in TBI. Also, the experimental animal model of TBI explored to understand the role of SIRTs in TBI have been discussed.
AB - Traumatic brain injury (TBI) can simply be defined as a violent external injury to the head causing brain dysfunction. The primary injury occurs immediately on impact whereas the secondary injury begins minutes to months after impact. TBI affects a vast majority of population worldwide yet, there isn't any therapeutic intervention available. Sirtuins (SIRTs) are important regulator proteins found in humans. In several neurodegenerative diseases, SIRTs have proven its neuroprotective actions. Owing to the pathophysiological similarities in these diseases and TBI, SIRTs may serve as a potential target for therapeutic intervention in TBI. This review aims to describe the relevance of SIRTs as a potential pharmacological target in TBI. Also, the experimental animal model of TBI explored to understand the role of SIRTs in TBI have been discussed.
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U2 - 10.1016/j.brainresbull.2021.03.016
DO - 10.1016/j.brainresbull.2021.03.016
M3 - Review article
AN - SCOPUS:85103537335
SN - 0361-9230
VL - 171
SP - 135
EP - 141
JO - Journal of Electrophysiological Techniques
JF - Journal of Electrophysiological Techniques
ER -