Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Utkarsh Bhutani; Anindita Laha; Kishalay Mitra; Saptarshi Majumdar

doi:10.1016/j.matlet.2015.10.114

Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Utkarsh Bhutani, Anindita Laha, Kishalay Mitra, Saptarshi Majumdar

Department of Chemical Engineering, Manipal Institute of Technology, Manipal

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.

Original language	English
Pages (from-to)	76-79
Number of pages	4
Journal	Materials Letters
Volume	164
DOIs	https://doi.org/10.1016/j.matlet.2015.10.114
Publication status	Published - 01-02-2016

All Science Journal Classification (ASJC) codes

Materials Science(all)
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2015.10.114

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abstract = "Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.",

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Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Abstract

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