Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Utkarsh Bhutani; Anindita Laha; Kishalay Mitra; Saptarshi Majumdar

doi:10.1016/j.matlet.2015.10.114

Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Utkarsh Bhutani
, Anindita Laha
, Kishalay Mitra
, Saptarshi Majumdar^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Abstract

Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.

Original language	English
Pages (from-to)	76-79
Number of pages	4
Journal	Materials Letters
Volume	164
DOIs	https://doi.org/10.1016/j.matlet.2015.10.114
Publication status	Published - 01-02-2016

All Science Journal Classification (ASJC) codes

General Materials Science
Condensed Matter Physics
Mechanics of Materials
Mechanical Engineering

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10.1016/j.matlet.2015.10.114

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abstract = "Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.",

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AU - Laha, Anindita

AU - Mitra, Kishalay

AU - Majumdar, Saptarshi

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AB - Blend of biodegradable hydrogels like sodium alginate/gelatin (SA/G) usually requires use of chemical cross-linkers to remain stable in aqueous media for drug delivery applications. This study targets the feasibility of having an entire spectrum of a model hydrophobic drug (piperine) release i.e. from burst to controlled release, by varying polymer viscosity and molecular weight of plasticizer with minimal use of cross-linkers. Swelling study, drug-polymer interactions and morphology analysis reveal the impact of viscosity variation on polymer matrix.

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JO - Materials Letters

JF - Materials Letters

ER -

Sodium alginate and gelatin hydrogels: Viscosity effect on hydrophobic drug release

Abstract

All Science Journal Classification (ASJC) codes

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