TY - JOUR
T1 - Sol–gel co-precipitation synthesis, anticoagulant and anti-platelet activities of copper-doped nickel manganite nanoparticles
AU - Shashidharagowda, H.
AU - Mathad, Shridhar
AU - Malladi, Shridhar
AU - Gubbiveeranna, Vinod
AU - Kusuma, C. G.
AU - Nagaraju, S.
AU - Patil, Arun Y.
AU - Khan, Anish
AU - Malik, Abdul Rub
AU - Asiri, Abdullah M.
AU - Azum, Naved
N1 - Funding Information:
Acknowledgments: The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number IFPIP: 106-130-1442 and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.
Funding Information:
Funding: The authors extend their appreciation to the Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia for funding this research work through the project number IFPIP-106-130-1442 and King Abdulaziz University, DSR, Jeddah, Saudi Arabia.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/12
Y1 - 2021/12
N2 - Copper-substituted nickel manganites Ni(1−x) Cux Mn2 O4 (Ni-TCE-NPs) were produced by co-precipitation route (sol–gel) at room temperature. Ni(1−x) CuxMn2 O4-Bio (NCB) NPs were studied by powder X-ray diffraction technique, scanning electron microscopy and Raman spectroscopy. XRD spectra authenticated the copper-doped nickel manganites’ formation with particle size 23–28 nm. A significant decrease in the lattice parameter confirmed the doping of copper ions into the nickel manganites. Microscopy (SEM) was used to estimate the grain size, shape and uniformity, revealing the non-uniform agglomerated polygon and plate-like microstructure. The NCB-NPs showed antico-agulant activity by enhancing the coagulation time of citrated plasma of human beings. NCB-NPs with x = 0.35 and 0.45 have increased clotting time from control 133 ± 4 s to 401 ± 7 s and 3554 ± 80 s, respectively, and others around 134 s. Additionally NCB-NPs with x = 0.35, 0.45 inhibited the platelet aggregation by 80% and 92%, while remaining inhibited with only 30%. NCB-NPs did not show hemolytic activity in RBC cells intimate its non-toxic nature. Finally, NCB-NPs were non-toxic and known to exhibit anti-blood-clotting and antiplatelet activities, which can be used in the field of biomedical applications, especially as antithrombotic agents.
AB - Copper-substituted nickel manganites Ni(1−x) Cux Mn2 O4 (Ni-TCE-NPs) were produced by co-precipitation route (sol–gel) at room temperature. Ni(1−x) CuxMn2 O4-Bio (NCB) NPs were studied by powder X-ray diffraction technique, scanning electron microscopy and Raman spectroscopy. XRD spectra authenticated the copper-doped nickel manganites’ formation with particle size 23–28 nm. A significant decrease in the lattice parameter confirmed the doping of copper ions into the nickel manganites. Microscopy (SEM) was used to estimate the grain size, shape and uniformity, revealing the non-uniform agglomerated polygon and plate-like microstructure. The NCB-NPs showed antico-agulant activity by enhancing the coagulation time of citrated plasma of human beings. NCB-NPs with x = 0.35 and 0.45 have increased clotting time from control 133 ± 4 s to 401 ± 7 s and 3554 ± 80 s, respectively, and others around 134 s. Additionally NCB-NPs with x = 0.35, 0.45 inhibited the platelet aggregation by 80% and 92%, while remaining inhibited with only 30%. NCB-NPs did not show hemolytic activity in RBC cells intimate its non-toxic nature. Finally, NCB-NPs were non-toxic and known to exhibit anti-blood-clotting and antiplatelet activities, which can be used in the field of biomedical applications, especially as antithrombotic agents.
UR - https://www.scopus.com/pages/publications/85121467464
UR - https://www.scopus.com/pages/publications/85121467464#tab=citedBy
U2 - 10.3390/gels7040269
DO - 10.3390/gels7040269
M3 - Article
AN - SCOPUS:85121467464
SN - 2310-2861
VL - 7
JO - Gels
JF - Gels
IS - 4
M1 - 269
ER -