TY - JOUR
T1 - Spermatogonial quantity in prepubertal boys undergoing fertility preservation is comparable between haematological and non-haematological cancers
AU - Tholeti, Prathima
AU - Koulmane Laxminarayana, Sindhura L.
AU - Lakshmi, Vani R.
AU - Bhat, Vasudeva K.
AU - Kumar P, Vijay
AU - Uppangala, Shubhashree
AU - Kalthur, Guruprasad
AU - Spears, Norah
AU - Adiga, Satish Kumar
N1 - Publisher Copyright:
© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Fertility restoration potential of immature testicular tissue (ITT) depends on the number of spermatogonial cells in the retrieved tissue prior to cryopreservation in oncofertility programme. There are limited data on the association between type of malignancy and testicular germ cell population. Hence, this study is aimed to investigate the spermatogonial and Sertoli cell population in ITT retrieved from 14 pre-pubertal boys who opted for fertility preservation. Histopathological and immunochemical analysis of seminiferous tubules from haematological (N = 7) and non-haematological (N = 7) malignant patients revealed 3.43 ± 2.92 and 1.71 ± 1.81 spermatogonia per tubular cross section (S/T), respectively. The Sertoli cell number was comparable between haematological and non-haematological group (18.42 ± 3.78 and 22.03 ± 10.43). Spermatogonial quantity in ITT did not vary significantly between haematological and non-haematological cancers. This observation, though preliminary, would contribute to the limited literature on paediatric male oncofertility.
AB - Fertility restoration potential of immature testicular tissue (ITT) depends on the number of spermatogonial cells in the retrieved tissue prior to cryopreservation in oncofertility programme. There are limited data on the association between type of malignancy and testicular germ cell population. Hence, this study is aimed to investigate the spermatogonial and Sertoli cell population in ITT retrieved from 14 pre-pubertal boys who opted for fertility preservation. Histopathological and immunochemical analysis of seminiferous tubules from haematological (N = 7) and non-haematological (N = 7) malignant patients revealed 3.43 ± 2.92 and 1.71 ± 1.81 spermatogonia per tubular cross section (S/T), respectively. The Sertoli cell number was comparable between haematological and non-haematological group (18.42 ± 3.78 and 22.03 ± 10.43). Spermatogonial quantity in ITT did not vary significantly between haematological and non-haematological cancers. This observation, though preliminary, would contribute to the limited literature on paediatric male oncofertility.
UR - http://www.scopus.com/inward/record.url?scp=85195356489&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85195356489&partnerID=8YFLogxK
U2 - 10.1080/14647273.2024.2362980
DO - 10.1080/14647273.2024.2362980
M3 - Article
C2 - 38842163
AN - SCOPUS:85195356489
SN - 1464-7273
VL - 27
SP - 2362980
JO - Human fertility (Cambridge, England)
JF - Human fertility (Cambridge, England)
IS - 1
M1 - 2362980
ER -
