TY - JOUR
T1 - Spontaneous tumour lysis syndrome in a case of multiple myeloma - A rare occurrence
AU - Saravu, Kavitha
AU - Kumar, Suresh
AU - Shastry, Ananthakrishna Barkur
AU - Kurien, Annamma
AU - Prabhu, Ravindra
AU - Kumar, Rishikesh
PY - 2013/4/5
Y1 - 2013/4/5
N2 - We describe a case of a 40-year-old male patient who was found to have multiple myeloma with spontaneous tumour lysis syndrome (TLS), following a compression fracture of the L-2 vertebrae. Multiple myeloma was confirmed by bone marrow analysis and the M-band on serum protein electrophoresis. Hyperuricaemia (26.2 mg/dL), hyperkalaemia (> 7.0 mEq/L), hyperphosphatemia (16.2 mg of phosphorus/dL), normocalcemia and acute kidney injury, prior to anticancer treatment suggested spontaneous TLS. Inciting events for tumour lysis, such as chemotherapy, dehydration and exposure to steroids were absent. Patient received hydration, hypourecemic drugs and haemodialysis. This case report highlights the rare presentation of multiple myeloma with spontaneous TLS.
AB - We describe a case of a 40-year-old male patient who was found to have multiple myeloma with spontaneous tumour lysis syndrome (TLS), following a compression fracture of the L-2 vertebrae. Multiple myeloma was confirmed by bone marrow analysis and the M-band on serum protein electrophoresis. Hyperuricaemia (26.2 mg/dL), hyperkalaemia (> 7.0 mEq/L), hyperphosphatemia (16.2 mg of phosphorus/dL), normocalcemia and acute kidney injury, prior to anticancer treatment suggested spontaneous TLS. Inciting events for tumour lysis, such as chemotherapy, dehydration and exposure to steroids were absent. Patient received hydration, hypourecemic drugs and haemodialysis. This case report highlights the rare presentation of multiple myeloma with spontaneous TLS.
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U2 - 10.4066/AMJ.2013.1592
DO - 10.4066/AMJ.2013.1592
M3 - Article
AN - SCOPUS:84875665769
SN - 1836-1935
VL - 6
SP - 168
EP - 171
JO - Australasian Medical Journal
JF - Australasian Medical Journal
IS - 3
ER -