TY - JOUR
T1 - Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer
AU - Padya, Bharath Singh
AU - Pandey, Abhijeet
AU - Pisay, Muralidhar
AU - Koteshwara, K. B.
AU - Chandrashekhar Hariharapura, Raghu
AU - Bhat, Kuruveri Udaya
AU - Biswas, Swati
AU - Mutalik, Srinivas
N1 - Funding Information:
The project was funded by AICTE and Manipal Academy of Higher Education.
Funding Information:
The authors are thankful to All India Council for Technical Education (AICTE), Government of India, New Delhi for granting National Doctoral Fellowship (NDF) to Bharath Singh Padya and to Manipal Academy of Higher Education, Manipal for providing Postdoctoral Research Fellowship to Dr Abhijeet Pandey.
Publisher Copyright:
© 2020 Elsevier B.V.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2021/1/5
Y1 - 2021/1/5
N2 - Interdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer. The review describes various polymeric, lipidic and inorganic nanoplatforms for efficient therapy of skin cancer. The stimuli-responsive nanoplatforms such as pH-responsive as well as temperature-responsive platforms have also been reviewed. Different strategies for potentiating the nanoparticles application for cancer therapy such as surface engineering, conjugation with drugs, stimulus-responsive and multimodal effect have also been discussed and compared with the available conventional treatments. Although, nanopharmaceuticals face challenges such as toxicity, cost and scale-up, efforts put-in to improve these drawbacks with continuous research would deliver exciting and promising results in coming days.
AB - Interdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer. The review describes various polymeric, lipidic and inorganic nanoplatforms for efficient therapy of skin cancer. The stimuli-responsive nanoplatforms such as pH-responsive as well as temperature-responsive platforms have also been reviewed. Different strategies for potentiating the nanoparticles application for cancer therapy such as surface engineering, conjugation with drugs, stimulus-responsive and multimodal effect have also been discussed and compared with the available conventional treatments. Although, nanopharmaceuticals face challenges such as toxicity, cost and scale-up, efforts put-in to improve these drawbacks with continuous research would deliver exciting and promising results in coming days.
UR - http://www.scopus.com/inward/record.url?scp=85095609099&partnerID=8YFLogxK
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U2 - 10.1016/j.ejphar.2020.173633
DO - 10.1016/j.ejphar.2020.173633
M3 - Review article
C2 - 33049302
AN - SCOPUS:85095609099
SN - 0014-2999
VL - 890
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
M1 - 173633
ER -
