Stomatitis associated with olanzapine and sodium valproate combination treatment

The purpose of this article is to draw attention towards possibility of drug reaction while starting a combination of sodium valproate and olanzapine for the treatment of acute mania. We describe four cases (three with bipolar disorder, current episode manic, one schizoaffective disorder, bipolar type), who developed stomatitis and pharyngitis within first week while on sodium valproate and olanzapine combination. In three out of four cases the symptoms resolved after withdrawing olanzapine and instituting symptomatic treatment.