Strain improvement of a new keratinolytic fungi

B. Venkatesh Kamath, Hawa Hashim, Kamesh Kumar Keshri, Swati Tripathy, V. M. Subrahmanyam

Research output: Contribution to journalArticlepeer-review


Keratinase is a protease enzyme. It degrades the keratin protein present in the hair, skin, nails etc. It can be applied in various fields of therapeutics such as in the treatment of onychomycosis, hair dandruff and recently in skin cancer as well. It can also be applied in various textile and leather industries. The SPF1 fungi isolated from the poultry farm around Manipal, India was found to produce the inducible keratinase enzyme. The strain was exposed to UV radiation to induce the UV mutation and the yield was found to have improved from 147.52µg/ml to 288.00µg/ml. The SPF1 strain was also plated in Sabouraud Dextrose Agar and 8 different colonies were selected to compare their keratinolytic activities.

Original languageEnglish
Pages (from-to)843-845
Number of pages3
JournalResearch Journal of Pharmacy and Technology
Issue number2
Publication statusPublished - 2021

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Pharmacology (medical)


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