TY - JOUR
T1 - Strategies towards Orthopaedic Tissue Engineered Graft Generation
T2 - Current Scenario and Application
AU - Mallick, Sarada Prasanna
AU - Beyene, Zerihun
AU - Suman, Dheerendra Kumar
AU - Madhual, Abhimanyu
AU - Singh, Bhisham Narayan
AU - Srivastava, Pradeep
N1 - Publisher Copyright:
© 2019, The Korean Society for Biotechnology and Bioengineering and Springer.
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Even though degradation and damage to bone and cartilage tissue can be resolved naturally, but there is a great challenge to regenerate functional tissue due to multiple pathological conditions. To treat the diseased/ damaged bone and cartilage tissue as well as to improve or maintain its natural functions and structure, there are different strategies being developed for repair and regeneration of these tissues. Various innovative researches lead to remarkable improvement in clinical outcome of defective bone and cartilage treatments. Biomaterial based scaffolds which are capable of supporting cell growth and applied for replacement of tissue in vivo for both bone and cartilage. The review also delineates about the tissue engineering bioreactors for the recreation of frameworks to recellularise the graft in vitro by presenting them to physiologically significant mechanical or potentially hydrodynamic stimulation condition. This review summarizes and discusses the strategies for regeneration and repair of bone and cartilage tissue, current scenario and application.
AB - Even though degradation and damage to bone and cartilage tissue can be resolved naturally, but there is a great challenge to regenerate functional tissue due to multiple pathological conditions. To treat the diseased/ damaged bone and cartilage tissue as well as to improve or maintain its natural functions and structure, there are different strategies being developed for repair and regeneration of these tissues. Various innovative researches lead to remarkable improvement in clinical outcome of defective bone and cartilage treatments. Biomaterial based scaffolds which are capable of supporting cell growth and applied for replacement of tissue in vivo for both bone and cartilage. The review also delineates about the tissue engineering bioreactors for the recreation of frameworks to recellularise the graft in vitro by presenting them to physiologically significant mechanical or potentially hydrodynamic stimulation condition. This review summarizes and discusses the strategies for regeneration and repair of bone and cartilage tissue, current scenario and application.
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U2 - 10.1007/s12257-019-0086-6
DO - 10.1007/s12257-019-0086-6
M3 - Review article
AN - SCOPUS:85076740105
SN - 1226-8372
VL - 24
SP - 854
EP - 869
JO - Biotechnology and Bioprocess Engineering
JF - Biotechnology and Bioprocess Engineering
IS - 6
ER -