Structural Activity Relationship based Medicinal Perspectives of Pyrimidine Derivatives as Anti-Alzheimer's Agents: A Comprehensive Review

Subham Das, Saleem Akbar, Bahar Ahmed, Rikeshwar Prasad Dewangan, Ashif Iqubal, Faheem Hyder Pottoo, Alex Joseph

Research output: Contribution to journalReview articlepeer-review

11 Citations (Scopus)

Abstract

Pyrimidine is an aromatic and heterocyclic organic compound containing a 6-membered ring consisting of four carbon and two nitrogen atoms on alternative positions. Pyrimidine scaffolds described their existence in the medicinal chemist's cause for their synthesizing practicability and nonpoisonous nature. However, the reason behind neurological disorders is still an open challenge for scientific research and development organizations. Efficacy voids are widespread before researchers, despite high throughput research in the field of anti-Alzheimer's drugs.Researchers have constantly investigated all the probabilities for restraining the unwanted adverse effects of the anti-Alzheimer's agents and are focusing more extensively to rehabilitate neurological disorders. The scientific literature on drug development has been an aspiration to medicinal chemists and other researchers to facilitate further research. Therefore, this review emphasizes the structure-activity relationship (SAR) based approach and the pharmacological advancements of pyrimidine moiety in the new era of therapeutics as anti-Alzheimer's agents.

Original languageEnglish
Pages (from-to)926-939
Number of pages14
JournalCNS & neurological disorders drug targets
Volume21
Issue number10
DOIs
Publication statusPublished - 2022

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • Pharmacology

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