TY - JOUR
T1 - Structural elucidation of a Mn(III) derivative anchored with a tetradentate Schiff base precursor
T2 - in vitro cytotoxicity study
AU - Das, Kuheli
AU - Shetty, Manasa G.
AU - Melanthota, Sindhoora K.
AU - Sundara, Babitha K.
AU - Kar, Sudeshna
AU - Massera, Chiara
AU - Garribba, Eugenio
AU - Datta, Amitabha
AU - Mazumder, Nirmal
N1 - Funding Information:
KD expresses her appreciation to the SERB (Science and Engineering Research Board, India) Grant (PDF/2016/002832) for financial assistance. AD would like to thank Prof. Chen-Hsiung Hung for providing the laboratory facility. NM thanks the Department of Science and Technology (DST) [Project Number- SERB/MTR/2020/000058] and the Indian Council of Medical Research (ICMR) [ICMR, ID No. 2020-3286], Government of India, India, for financial support. KSB thanks Department of Biotechnology (DBT), Government of India, India for BIOCARE project (Project Number-No. BT/PR20046/BIC/683/2016). MS, SKM, BKS, NM thank Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India, for providing the infrastructure and facilities.
Funding Information:
KD expresses her appreciation to the SERB (Science and Engineering Research Board, India) Grant (PDF/2016/002832) for financial assistance. AD would like to thank Prof. Chen-Hsiung Hung for providing the laboratory facility. NM thanks the Department of Science and Technology (DST) [Project Number- SERB/MTR/2020/000058] and the Indian Council of Medical Research (ICMR) [ICMR, ID No. 2020-3286], Government of India, India, for financial support. KSB thanks Department of Biotechnology (DBT), Government of India, India for BIOCARE project (Project Number-No. BT/PR20046/BIC/683/2016). MS, SKM, BKS, NM thank Manipal School of Life Sciences, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka, India, for providing the infrastructure and facilities.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/4
Y1 - 2023/4
N2 - A new mononuclear Mn(III) derivative, [Mn(L)(H2O)2]ClO4 (1) was obtained by reacting manganese perchlorate with the tetradentate Schiff base precursor, H2L, [where H2L=C6H3(OMe)(OH)CH=N(CH2)3N=CH(OH)(OMe)C6H3] and characterized by various spectral techniques. Single crystal X-ray diffraction analysis revealed that in 1, the central Mn atom is hexa-coordinated via the NNOO donor sites of the Schiff base precursor and two water molecules, yielding a distorted octahedral geometry. Also, the EPR spectra of 1 were recorded at the solid state by varying the temperature (from 90 to 300 K) as well as in different organic solvents; DMSO, MeOH and a mixture CH2Cl2/toluene; the results obtained agree with the geometrical environment around the metal. The cytotoxic activity of the Mn(III) derivative was evaluated against normal and cancer cell lines. The derivative exhibited comparatively better cytotoxic activity against MCF-7 cells compared to SiHa and fibroblast cells.
AB - A new mononuclear Mn(III) derivative, [Mn(L)(H2O)2]ClO4 (1) was obtained by reacting manganese perchlorate with the tetradentate Schiff base precursor, H2L, [where H2L=C6H3(OMe)(OH)CH=N(CH2)3N=CH(OH)(OMe)C6H3] and characterized by various spectral techniques. Single crystal X-ray diffraction analysis revealed that in 1, the central Mn atom is hexa-coordinated via the NNOO donor sites of the Schiff base precursor and two water molecules, yielding a distorted octahedral geometry. Also, the EPR spectra of 1 were recorded at the solid state by varying the temperature (from 90 to 300 K) as well as in different organic solvents; DMSO, MeOH and a mixture CH2Cl2/toluene; the results obtained agree with the geometrical environment around the metal. The cytotoxic activity of the Mn(III) derivative was evaluated against normal and cancer cell lines. The derivative exhibited comparatively better cytotoxic activity against MCF-7 cells compared to SiHa and fibroblast cells.
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U2 - 10.1007/s11696-022-02599-x
DO - 10.1007/s11696-022-02599-x
M3 - Article
AN - SCOPUS:85145585459
SN - 0366-6352
VL - 77
SP - 1989
EP - 1998
JO - Chemical Papers
JF - Chemical Papers
IS - 4
ER -
